Title:
CARBAZOLE DERIVATIVE KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/119481
Kind Code:
A1
Abstract:
Provided is a kinase inhibitor, comprising a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite, or a prodrug thereof. Further provided are a pharmaceutical composition comprising the kinase inhibitor, and a use and a method for using the compound or the composition to inhibit the activity of one or more tyrosine kinases selected from cKIT, BCR/ABL, PDGFRα, PDGFRß, and VEGFR2 in a cell or a subject, and to prevent or treat a kinase-related disorder in a subject.
Inventors:
LIU JING (CN)
LIU QINGSONG (CN)
LIU XUESONG (CN)
WANG BEILEI (CN)
JIANG ZONGRU (CN)
YU KAILIN (CN)
CHEN CHENG (CN)
ZOU FENGMING (CN)
LIU QINGWANG (CN)
LIU XIAOCHUAN (CN)
WANG WEI (CN)
WANG WENLIANG (CN)
HU CHEN (CN)
WANG WENCHAO (CN)
WANG JUNJIE (CN)
WANG LI (CN)
LIU QINGSONG (CN)
LIU XUESONG (CN)
WANG BEILEI (CN)
JIANG ZONGRU (CN)
YU KAILIN (CN)
CHEN CHENG (CN)
ZOU FENGMING (CN)
LIU QINGWANG (CN)
LIU XIAOCHUAN (CN)
WANG WEI (CN)
WANG WENLIANG (CN)
HU CHEN (CN)
WANG WENCHAO (CN)
WANG JUNJIE (CN)
WANG LI (CN)
Application Number:
PCT/CN2017/118602
Publication Date:
June 27, 2019
Filing Date:
December 26, 2017
Export Citation:
Assignee:
HEFEI INST PHYSICAL SCI CAS (CN)
International Classes:
C07D231/56; A61K31/416; A61P35/00; C07D401/06; C07D401/12; C07D401/14
Domestic Patent References:
| WO2012003418A2 | 2012-01-05 |
Foreign References:
| CN1747950A | 2006-03-15 | |||
| CN101005843A | 2007-07-25 | |||
| CN102239150A | 2011-11-09 | |||
| CN105906568A | 2016-08-31 | |||
| CN101056870A | 2007-10-17 | |||
| CN101052634A | 2007-10-10 |
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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