Title:
CARBOCYCLIC NUCLEOSIDE DERIVATIVE AND ANTIVIRAL AGENT COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2018/131950
Kind Code:
A1
Abstract:
The present invention relates to a carbocyclic nucleoside derivative represented by chemical formula A or a pharmaceutically acceptable salt thereof, and an antiviral agent comprising the same.
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Inventors:
JEONG LAK SHIN (KR)
SHIN YOUNG SUP (KR)
KIM GYU DONG (KR)
YUN JI SEONG (KR)
KIM HONG RAE (KR)
KIM HEA OK (KR)
SAHU PRAMOD KUMAR (KR)
LIMA LEITE OGANDO S NATACHA (NL)
KOVACIKOVA KRISTINA (NL)
POSTHUMA C CLARA (NL)
SNIJDER J ERIC (NL)
VAN HEMERT J MARTIJN (NL)
SHIN YOUNG SUP (KR)
KIM GYU DONG (KR)
YUN JI SEONG (KR)
KIM HONG RAE (KR)
KIM HEA OK (KR)
SAHU PRAMOD KUMAR (KR)
LIMA LEITE OGANDO S NATACHA (NL)
KOVACIKOVA KRISTINA (NL)
POSTHUMA C CLARA (NL)
SNIJDER J ERIC (NL)
VAN HEMERT J MARTIJN (NL)
Application Number:
PCT/KR2018/000644
Publication Date:
July 19, 2018
Filing Date:
January 12, 2018
Export Citation:
Assignee:
FUTURE MEDICINE CO LTD (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07H19/167; A61K31/7076; C07H19/04
Foreign References:
| US4605659A | 1986-08-12 |
Other References:
YANG, M. ET AL.: "5'-Homoaristeromycin. Synthesis and Antiviral Activity against Orthopox Virus", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 3 January 2005 (2005-01-03), pages 149 - 151, XP027800848
YIN, X.-Q. ET AL.: "Chiral Syntheses of 6'beta-fluoroaristeromycin, 6'-beta-fluoro-5'-noraristeromycin and Aristeromycin", TETRAHEDRON LETTERS, vol. 46, 19 September 2005 (2005-09-19), pages 7535 - 7538, XP002680404
COOLS, M. ET AL.: "Mechanism of Antiviral and Cytotoxic Action of (±)-6' beta-fluoroansteromycin. a Potent Inhibitor of S-Adenosylhomocysteine Hydrolase", MOLECULAR PHARMACOLOGY, vol. 39, no. 6, June 1991 (1991-06-01), pages 718 - 724
YANG, M. ET AL.: "6'-Methyl-5'-homoaristeromycin: A Structural Variation of the Anti-orthopox Vims Candidate 5'-homoaristeromycin", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4374 - 4377
YIN, X.-Q. ET AL.: "Chiral Syntheses of 6'beta-fluoroaristeromycin, 6'-beta-fluoro-5'-noraristeromycin and Aristeromycin", TETRAHEDRON LETTERS, vol. 46, 19 September 2005 (2005-09-19), pages 7535 - 7538, XP002680404
COOLS, M. ET AL.: "Mechanism of Antiviral and Cytotoxic Action of (±)-6' beta-fluoroansteromycin. a Potent Inhibitor of S-Adenosylhomocysteine Hydrolase", MOLECULAR PHARMACOLOGY, vol. 39, no. 6, June 1991 (1991-06-01), pages 718 - 724
YANG, M. ET AL.: "6'-Methyl-5'-homoaristeromycin: A Structural Variation of the Anti-orthopox Vims Candidate 5'-homoaristeromycin", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4374 - 4377
Attorney, Agent or Firm:
KASAN IP & LAW FIRM (KR)
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