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Patent Searching and Data


Title:
CARBOHYDRATE PHOSPHONATE DERIVATIVES AS MODULATORS OF GLYCOSYLATION
Document Type and Number:
WIPO Patent Application WO/2014/130613
Kind Code:
A3
Abstract:
Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other variables are provided herein.

Inventors:
ALLEN, John Gordon (5255 Via Capote, Newbury Park, California, 91320, US)
FOTSCH, Christopher H. (533 Timberwood Avenue, Thousand Oaks, California, 91360, US)
FROHN, Michael J. (2808 Cedar Wood Place, Thousand Oaks, California, 91362, US)
MCCARTER, John Douglas (860 Jasper Avenue, Ventura, California, 93004, US)
MUJACIC, Mirna (1408 12th Avenue, Apt 210Seattle, Washington, 98122, US)
PICKRELL, Alexander J. (30948 Minute Man Way, Westlake Village, California, 91361, US)
Application Number:
US2014/017271
Publication Date:
August 28, 2014
Filing Date:
February 20, 2014
Export Citation:
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Assignee:
AMGEN INC. (One Amgen Center Drive, Thousand Oaks, California, 91320-1799, US)
International Classes:
C07D309/10; C07D309/14; C12P17/06
Domestic Patent References:
2009-11-05
2010-12-09
2006-11-16
Other References:
YU-NONG LIN ET AL: "Chemoenzymatic Synthesis of GDP-L-Fucose Derivatives as Potent and Selective [alpha]-1,3-Fucosyltransferase Inhibitors", ADVANCED SYNTHESIS & CATALYSIS, vol. 354, no. 9, 18 June 2012 (2012-06-18), pages 1750 - 1758, XP055117413, ISSN: 1615-4150, DOI: 10.1002/adsc.201100940
CORY D. RILLAHAN ET AL: "High-Throughput Screening for Inhibitors of Sialyl- and Fucosyltransferases", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 50, no. 52, 23 December 2011 (2011-12-23), pages 12534 - 12537, XP055117415, ISSN: 1433-7851, DOI: 10.1002/anie.201105065
Attorney, Agent or Firm:
FRIEDRICHSEN, Bernard P. (Amgen Inc, M/S 28-2-COne Amgen Center Driv, Thousand Oaks California, 91320-1799, US)
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