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Title:
CARBOLINE DERIVATIVES OR PHOSPHOROUS DERIVATIVES FOR THE PREVENTION OR TREATMENT OF MUSCULAR MYOPATHIES AND TRAUMATIC INJURIES TO MUSCLES
Document Type and Number:
WIPO Patent Application WO/2017/098173
Kind Code:
A3
Abstract:
The invention relates to the field of medicine. More specifically, the invention relates to the use of compounds, on a patient, in order to prevent and/or treat myopathy, typically muscular dystrophy or cardiomyopathy, or a traumatic injury to muscle. The invention also relates to compositions, particularly pharmaceutical compositions comprising such compounds, and to the use thereof in order to prevent and/or treat myopathy or a traumatic injury to muscle. The compounds and compositions according to the invention can typically be used advantageously to prevent and/or treat muscular dystrophy, cardiomyopathy or a traumatic injury to muscle, preferably Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and/or a symptom or a characteristic anomaly of DMD or BMD.

Inventors:
CANCELA, José-Manuel (4 rue Jeanne d'Arc, Palaiseau, 91120, FR)
DE LA PORTE, Sabine (86 rue Royale, Versailles, 78000, FR)
DE ZELICOURT, Antoine (28 rue Carnot, Versailles, 78000, FR)
Application Number:
FR2016/053289
Publication Date:
June 15, 2017
Filing Date:
December 09, 2016
Export Citation:
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Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (3 rue Michel Ange, Paris, 75016, FR)
International Classes:
A61K31/496; A61K31/706; A61K31/7064; A61K31/7076; A61K31/7084; A61P21/00
Domestic Patent References:
2011-01-06
2009-08-20
Foreign References:
US20120308542A12012-12-06
ITFI20070077A12008-09-29
US20090306006A12009-12-10
Other References:
MICHELLE F. GOODY ET AL: "NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy", PLOS BIOLOGY, vol. 10, no. 10, 23 October 2012 (2012-10-23), pages e1001409, XP055291295, DOI: 10.1371/journal.pbio.1001409
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; QU, HONGYAN ET AL: "Protective effect of nicotinamide adenine dinucleotide on adriamycin-induced cardiomyopathy in rats", XP002760361, retrieved from STN Database accession no. 2008:1345956
ANNA KA YEE KWONG ET AL: "Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38", BIOCHEMISTRY, vol. 51, no. 1, 10 January 2012 (2012-01-10), pages 555 - 564, XP055078673, ISSN: 0006-2960, DOI: 10.1021/bi201509f
HONG JIANG ET AL: "Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 5, 11 February 2009 (2009-02-11), US, pages 1658 - 1659, XP055291340, ISSN: 0002-7863, DOI: 10.1021/ja808387g
RUEGG UT: "Pharmacological prospects in the treatment of Duchenne muscular dystrophy", CURRENT OPINION IN NEUROLOGY, RAPID SCIENCE PUBLISHERS, LONDON, GB, vol. 26, no. 5, 1 October 2013 (2013-10-01), pages 577 - 584, XP009191136, ISSN: 1350-7540
LOPEZ JOSE R ET AL: "Altered Ca2+ Homeostasis in Human Uremic Skeletal Muscle: Possible Involvement of cADPR in Elevation of Intracellular Resting [Ca2+]", NEPHRON, S. KARGER AG, SWITZERLAND, vol. 100, no. 4, 1 January 2005 (2005-01-01), pages p51 - p60, XP009191127, ISSN: 0028-2766
Attorney, Agent or Firm:
STARCK-LOUDES, Anne-Caroline (Cabinet Becker, 25 rue Louis le Grand, Paris, 75002, FR)
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