Title:
CARBON NANOHORN FOR ENCAPSULATING AND CARRYING BORON COMPOUND ON OUTER WALL, AND METHOD FOR PRODUCING CARBON NANOHORN
Document Type and Number:
WIPO Patent Application WO/2015/156385
Kind Code:
A1
Abstract:
The purpose of the present invention is to overcome the problem of low tumor accumulation of boron in a boron formulation used in conventional boron neutron capture therapy, and to provide a boron formulation having high boron tumor accumulation; using carbon nanohorns for encapsulating a boron compound (BN-CNH) as the active ingredient of a boron neutron capture therapy formulation makes it possible to deliver the boron compound selectively to the tumor cells and to raise the boron tumor accumulation. This BN-CNH is preferably produced using ammonia borane as a raw material by heating together with carbon nanohorns.
Inventors:
IIZUMI YOKO (JP)
OKAZAKI TOSHIYA (JP)
YUDASAKA MASAKO (JP)
IKEHARA YUZURU (JP)
ZHANG MINFANG (JP)
OKAZAKI TOSHIYA (JP)
YUDASAKA MASAKO (JP)
IKEHARA YUZURU (JP)
ZHANG MINFANG (JP)
Application Number:
PCT/JP2015/061209
Publication Date:
October 15, 2015
Filing Date:
April 10, 2015
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
International Classes:
C01B31/02; A61K9/51; A61K33/22; A61K47/04; A61K47/22; A61K47/24; A61P35/00; B82Y5/00; B82Y40/00
Foreign References:
| JP2013057577A | 2013-03-28 | |||
| JP2005053904A | 2005-03-03 | |||
| JP2004256370A | 2004-09-16 | |||
| JP2006502993A | 2006-01-26 |
Other References:
MAKI NAKAMURA ET AL.: "Single-walled Carbon Nanohorns as Drug Carriers: Adsorption of Prednisolone and Anti-inflammatory Effects on Arthritis", FULLERENE-NANOTUBES GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 1.39th, 2010, pages 81
M.ZHANG ET AL.: "In Vivo Study of SWNHs with Different Sizes on Biodistribution", FULLERENE- NANOTUBES GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 38 th, 2010, pages 121
RYOTA YUGE ET AL.: "Preparation and structural properties of BN-doped carbon nanohorn aggregates", THE FULLERENES, NANOTUBES AND GRAPHENE GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 45 th, pages 89
FRANCISCO TORRENS ET AL.: "Solvent features of cluster single-wall C, BC2N and BN nanotubes, cones and horns", MICROELECTRONIC ENGINEERING, vol. 108, August 2013 (2013-08-01), pages 127 - 133, XP028563435
MANABU HARADA ET AL.: "Boron doped Nanohorn Aggregates Produced by means of Arc Discharge", THE FULLERENES, NANOTUBES AND GRAPHENE GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 33, pages 112
Y.FUKUNAGA ET AL.: "Variable range hopping conduction and percolation networks in the pellets formed from pristine and boron-doped carbon nanohorn particles", APPLIED PHYSICS A, vol. 94, no. 1, January 2009 (2009-01-01), pages 5 - 9, XP019655923, ISSN: 1432-0630
M.ZHANG ET AL.: "In Vivo Study of SWNHs with Different Sizes on Biodistribution", FULLERENE- NANOTUBES GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 38 th, 2010, pages 121
RYOTA YUGE ET AL.: "Preparation and structural properties of BN-doped carbon nanohorn aggregates", THE FULLERENES, NANOTUBES AND GRAPHENE GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 45 th, pages 89
FRANCISCO TORRENS ET AL.: "Solvent features of cluster single-wall C, BC2N and BN nanotubes, cones and horns", MICROELECTRONIC ENGINEERING, vol. 108, August 2013 (2013-08-01), pages 127 - 133, XP028563435
MANABU HARADA ET AL.: "Boron doped Nanohorn Aggregates Produced by means of Arc Discharge", THE FULLERENES, NANOTUBES AND GRAPHENE GENERAL SYMPOSIUM KOEN YOSHISHU, vol. 33, pages 112
Y.FUKUNAGA ET AL.: "Variable range hopping conduction and percolation networks in the pellets formed from pristine and boron-doped carbon nanohorn particles", APPLIED PHYSICS A, vol. 94, no. 1, January 2009 (2009-01-01), pages 5 - 9, XP019655923, ISSN: 1432-0630
Attorney, Agent or Firm:
ETO Yasuko (JP)
Yasuko Eto (JP)
Yasuko Eto (JP)
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