Title:
CARBONIC ANHYDRASE ACTIVATORS FOR ENHANCING LEARNING AND MEMORY
Document Type and Number:
WIPO Patent Application WO2002087423
Kind Code:
A3
Abstract:
The invention provides a method for improving attentive cognition comprising administering a compound that potentiates intraneuronal carbonic anhydrase activity thereby improving establishment of a theta rhythm.
Inventors:
ALKON DANIEL (US)
SUN MIAO-KUN (US)
SUN MIAO-KUN (US)
Application Number:
PCT/US2002/013784
Publication Date:
February 27, 2003
Filing Date:
May 02, 2002
Export Citation:
Assignee:
BRNI NEUROSCIENCES INST (US)
ALKON DANIEL (US)
SUN MIAO-KUN (US)
ALKON DANIEL (US)
SUN MIAO-KUN (US)
International Classes:
A61K31/137; A61K31/198; A61K31/4164; A61K31/417; A61K31/4172; A61K31/4178; A61P25/00; A61P25/28; A61P43/00; (IPC1-7): A61K31/417; A61K31/4172; A61K31/198
Domestic Patent References:
| WO2001093744A2 | 2001-12-13 | |||
| WO1985003869A1 | 1985-09-12 |
Foreign References:
| EP0387867A1 | 1990-09-19 | |||
| US5972684A | 1999-10-26 |
Other References:
SUN ET AL.: "Pharmacological enhancement of synaptic efficacy, spacial learning and memory through carbonic anhydrase activation in rats", PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 297, no. 3, June 2001 (2001-06-01), pages 961 - 967, XP002959205
SUN ET AL.: "Theta rhythm of hippocampal CA1 neuron activity: gating by GABAergic synaptic depolarization", THE JOURNAL OF NEUROPHYSIOLOGY, vol. 85, no. 1, January 2001 (2001-01-01), pages 269 - 279, XP002959204
SUPURAN ET AL.: "Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acid)ethyl-1H-imidazole", ENZYME INHIBITION, vol. 15, no. 5, 2000, pages 471 - 486, XP002959217
BRIGANTI ET AL.: "Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine", BIOCHEMISTRY, vol. 36, 1997, pages 10384 - 10392, XP002959203
SUN ET AL.: "Theta rhythm of hippocampal CA1 neuron activity: gating by GABAergic synaptic depolarization", THE JOURNAL OF NEUROPHYSIOLOGY, vol. 85, no. 1, January 2001 (2001-01-01), pages 269 - 279, XP002959204
SUPURAN ET AL.: "Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acid)ethyl-1H-imidazole", ENZYME INHIBITION, vol. 15, no. 5, 2000, pages 471 - 486, XP002959217
BRIGANTI ET AL.: "Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine", BIOCHEMISTRY, vol. 36, 1997, pages 10384 - 10392, XP002959203
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