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Title:
CARBONYL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO2004110418
Kind Code:
A3
Abstract:
Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Inventors:
WASH PAUL L (US)
WILEY BRANDON M (US)
HASSIG CHRISTIAN (US)
MALECHA JAMES W (US)
NOBLE STEWART A (US)
Application Number:
PCT/US2004/018502
Publication Date:
March 17, 2005
Filing Date:
June 10, 2004
Export Citation:
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Assignee:
KALYPSYS INC (US)
WASH PAUL L (US)
WILEY BRANDON M (US)
HASSIG CHRISTIAN (US)
MALECHA JAMES W (US)
NOBLE STEWART A (US)
International Classes:
C07C323/49; C07C323/67; C07C327/30; C07D277/16; C07D277/36; C07D277/52; C07D295/112; C07D319/18; C07D417/12; (IPC1-7): C07C331/04; A61K31/12; A61K31/167; A61K31/26; A61K31/357; A61K31/426; C07C323/22; C07C323/29; C07C323/67; C07C331/10; C07C331/12; C07D277/16; C07D277/36; C07D277/52; C07D319/18
Domestic Patent References:
WO2001070675A22001-09-27
WO2002069947A22002-09-12
WO2002020500A22002-03-14
WO2001090100A12001-11-29
Foreign References:
DE2436263A11976-02-12
EP0055458A21982-07-07
Other References:
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002310127, retrieved from STN
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002310128, retrieved from STN
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002310129, Database accession no. BRN 5532185
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002310130, Database accession no. BRN 7994375
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002310131, Database accession no. BRN 506166
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002310132, Database accession no. BRN 7929777
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002310133, Database accession no. BRN 7777930
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