Title:
CARBORANE COMPOUND, SALT THEREOF OR SOLVATE OF SAME
Document Type and Number:
WIPO Patent Application WO/2022/092068
Kind Code:
A1
Abstract:
The present invention provides a small molecule drug that is an agonist to T cell receptor CD28. Also, the present invention develops a lead compound in drug development, said lead compound being capable of suppressing autoimmune diseases and enhancing antitumor immune responses. A carborane compound represented by formula (1), a salt thereof or a solvate of the same (in the formula: R1 represents an amide bond-containing group; R2 and R3 are the same or different and represent a group containing a nitrogen-containing heterocycle; ● represents a carbon atom; and ○ represents a boron atom).
Inventors:
NAKAMURA HIROYUKI (JP)
ASAWA YASUNOBU (JP)
ODA MASAYUKI (JP)
ASAWA YASUNOBU (JP)
ODA MASAYUKI (JP)
Application Number:
PCT/JP2021/039442
Publication Date:
May 05, 2022
Filing Date:
October 26, 2021
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
TOKYO INST TECH (JP)
TOKYO INST TECH (JP)
International Classes:
C07F5/02; A61K33/22; A61P35/00; A61P37/02; A61P43/00
Domestic Patent References:
| WO2017026276A1 | 2017-02-16 |
Foreign References:
| JP2018533621A | 2018-11-15 |
Other References:
ASAWA, Y. ET AL.: "Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 27, 2019, pages 2832 - 2844, XP085704968, DOI: 10.1016/j.bmc. 2019.05.01 3
ENDO, Y ET AL.: "Polymethylcarborane as a Novel Bioactive Moiety: Derivatives with Potent Retinoid Antagonistic Activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, 2000, pages 1733 - 1736, XP004213234, DOI: 10.1016/S0960-894X(00)00327-9
HOPPENZ, P. ET AL.: "A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 85, 9 December 2019 (2019-12-09), pages 1446 - 1457, XP055769648, DOI: 10.1021/acsjoc.9b02406
ENDO, Y ET AL.: "Polymethylcarborane as a Novel Bioactive Moiety: Derivatives with Potent Retinoid Antagonistic Activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, 2000, pages 1733 - 1736, XP004213234, DOI: 10.1016/S0960-894X(00)00327-9
HOPPENZ, P. ET AL.: "A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 85, 9 December 2019 (2019-12-09), pages 1446 - 1457, XP055769648, DOI: 10.1021/acsjoc.9b02406
Attorney, Agent or Firm:
GOTO & CO. (JP)
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