Title:
CARBOXAMIDE INHIBITORS OF TGFB
Document Type and Number:
WIPO Patent Application WO2006105222
Kind Code:
A3
Abstract:
Pyrimidine having a pyridylamine group at C- 4 of the pyrimidine and an amide group on the pyridine ring (compounds of formula I) are useful in the treatment of conditions associated with excessive TGFB activity.
Inventors:
AXON JONATHAN (US)
CHAKRAVARTY SARVAJIT (US)
HART BARRY (US)
MCENROE GLENN (US)
MURPHY ALISON (US)
PONTIUS KAREN (US)
SHENG PEIJUE (US)
WANG XIAOJING (US)
YELLAPREGADA SHANTHI (US)
CHAKRAVARTY SARVAJIT (US)
HART BARRY (US)
MCENROE GLENN (US)
MURPHY ALISON (US)
PONTIUS KAREN (US)
SHENG PEIJUE (US)
WANG XIAOJING (US)
YELLAPREGADA SHANTHI (US)
Application Number:
PCT/US2006/011509
Publication Date:
December 28, 2006
Filing Date:
March 27, 2006
Export Citation:
Assignee:
SCIOS INC (US)
AXON JONATHAN (US)
CHAKRAVARTY SARVAJIT (US)
HART BARRY (US)
MCENROE GLENN (US)
MURPHY ALISON (US)
PONTIUS KAREN (US)
SHENG PEIJUE (US)
WANG XIAOJING (US)
YELLAPREGADA SHANTHI (US)
AXON JONATHAN (US)
CHAKRAVARTY SARVAJIT (US)
HART BARRY (US)
MCENROE GLENN (US)
MURPHY ALISON (US)
PONTIUS KAREN (US)
SHENG PEIJUE (US)
WANG XIAOJING (US)
YELLAPREGADA SHANTHI (US)
International Classes:
C07D401/12; A61K31/506; A61K31/5377; A61P11/00; A61P35/00; C07D401/14; C07D407/14; C07H7/06; C07H13/04; C07H15/04; C07H15/18; C07H15/26
Domestic Patent References:
| WO2004024159A1 | 2004-03-25 | |||
| WO2001047897A1 | 2001-07-05 |
Other References:
BELL I M ET AL: "Development of orally active oxytocin antagonists: Studies on 1-(1-{4- [1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy].2methoxyben zoyl}- 4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines", JOURNAL OF MEDICINAL CHEMISTRY 04 JUN 1998 UNITED STATES, vol. 41, no. 12, 4 June 1998 (1998-06-04), pages 2146 - 2163, XP002402890, ISSN: 0022-2623
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