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Title:
CARBOXYLIC ACID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/123016
Kind Code:
A1
Abstract:
Disclosed is a compound having a GPR40 agonistic activity and useful for use in a pharmaceutical composition or useful as an insulin secretion promoter or a prophylactic or therapeutic agent for diabetes. Extensive studies have been made on compounds having a GPR40 agonistic activity. As a result, it is found that a compound (I) having a carboxylic acid bound to the second or third ring moiety through a methylene group or having a benzene ring bound to the second or third ring moiety through a group –O-methylene -NH-methylene, wherein the benzene ring has been substituted by a 6-membered monocyclic aromatic ring, or a pharmaceutically acceptable salt of the compound (I) has an excellent GPR40 agonistic activity. It is also found that the compound has an excellent insulin secretion-promoting activity and can prevent the increase in a blood glucose level after glucose tolerance aggressively.

Inventors:
NEGORO KENJI (JP)
OHNUKI KEI (JP)
YONETOKU YASUHIRO (JP)
KURAMOTO KAZUYUKI (JP)
URANO YASUHARU (JP)
WATANABE HIDEYUKI (JP)
Application Number:
PCT/JP2010/057034
Publication Date:
October 28, 2010
Filing Date:
April 21, 2010
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
NEGORO KENJI (JP)
OHNUKI KEI (JP)
YONETOKU YASUHIRO (JP)
KURAMOTO KAZUYUKI (JP)
URANO YASUHARU (JP)
WATANABE HIDEYUKI (JP)
International Classes:
C07C43/225; A61K31/40; A61K31/4015; A61P3/10; C07C49/417; C07C69/76; C07C235/18; C07C303/36; C07D207/06; C07D207/27; C07D239/34; C07D305/06; C07D307/94; C07D309/06; C07D309/10; C07D317/22; C07D405/12; C07K14/705; C12N15/09
Domestic Patent References:
WO2005087710A12005-09-22
WO2004106276A12004-12-09
WO2008001931A22008-01-03
WO2009111056A12009-09-11
WO2004041266A12004-05-21
WO2005063729A12005-07-14
WO2005063725A12005-07-14
WO2005087710A12005-09-22
WO2004106276A12004-12-09
WO2008001931A22008-01-03
WO2008066097A12008-06-05
Foreign References:
JP2000212174A2000-08-02
JPH072848A1995-01-06
Other References:
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Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
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