CARBOXYLIC ACID TYPE LIPID

WIPO Patent Application WO/2002/038530

A1

A carboxylic acid type lipid which is a negatively charged lipid capable of stably donating negative charges to the surface of endoplasmic reticula without producing any side effect. It is represented by the following general formula [1]: [1] wherein R¿1?, R¿2?, and R¿3? each is a substituent, and one of these is represented by the general formula [X] [X] (wherein M is hydrogen or a monovalent cation and m, indicating the length of the methylene chain, is an integer of 1 to 5) and the remainder each is a chain hydrocarbon group; A¿1?, A¿2?, and A¿3? are the same or different and each is a group selected among C(O)O, CONH, and NHCO; and n, indicating the length of the methylene chain, is an integer of 1 to 3.

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TSUCHIDA EISHUN (JP)
TAKEOKA SHINJI (JP)
SOU KEITARO (JP)
OHKAWA HARUKI (JP)
MORI KATSURA (JP)

PCT/JP2001/009829

May 16, 2002

November 09, 2001

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JAPAN SCIENCE & TECH CORP (JP)
TSUCHIDA EISHUN (JP)
TAKEOKA SHINJI (JP)
SOU KEITARO (JP)
OHKAWA HARUKI (JP)
MORI KATSURA (JP)

A61K9/127; C07C69/44; C07C69/704; C07C233/47; C07C237/22; C07C323/52; C07C323/60; C07H13/04; C07H15/04; (IPC1-7): C07C69/44; C07C69/708; C07C233/47; C07C237/22; C07C321/14; C07H137/04; C07H15/04; A61K47/12; A61K47/26; A61K9/127; B01J13/02

WO1996024617A1

1996-08-15

US5370877A	1994-12-06
EP0099177A1	1984-01-25
JPH08277480A	1996-10-22
JPS6426777A	1989-01-30
US4873322A	1989-10-10
US6096801A	2000-08-01

See also references of EP 1340740A4

Nishizawa, Toshio (Udagawa-cho Shibuya-ku, Tokyo, JP)

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