Title:
CARBOXYLIC ACID URAT1 INHIBITOR CONTAINING DIARYLMETHANE STRUCTURE, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/173503
Kind Code:
A1
Abstract:
The present invention relates to the field of drugs for hyperuricemia and gout. In particular, the present invention relates to a carboxylic acid uric acid transporter 1 (URAT1) inhibitor of general formula (I) containing a diarylmethane structure and a preparation method thereof, and pharmaceutical compositions containing same and a use thereof in the preparation of drugs for treating hyperuricemia and gout, wherein R1 is selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, F, Cl, Br, I, CN, NO2, SR4 or OR4; R2 is selected from H, F, Cl, Br or I; R3 is selected from H or C1-C4 alkyl; X is selected from the CH2 or S; wherein R4 is selected from C1-C10 alkyl.
Inventors:
ZHAO GUILONG (CN)
LIU WEI (CN)
SHANG QIAN (CN)
ZHOU ZHIXING (CN)
WANG YULI (CN)
LI YUQUAN (CN)
ZHANG HAIZHI (CN)
LI CHUAN (CN)
LIU CHANGYING (CN)
LIU YUQIANG (CN)
XIE YAFEI (CN)
WU JINGWEI (CN)
CHEN HUIHUI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
LIU WEI (CN)
SHANG QIAN (CN)
ZHOU ZHIXING (CN)
WANG YULI (CN)
LI YUQUAN (CN)
ZHANG HAIZHI (CN)
LI CHUAN (CN)
LIU CHANGYING (CN)
LIU YUQIANG (CN)
XIE YAFEI (CN)
WU JINGWEI (CN)
CHEN HUIHUI (CN)
XU WEIREN (CN)
TANG LIDA (CN)
Application Number:
PCT/CN2016/080468
Publication Date:
November 03, 2016
Filing Date:
April 28, 2016
Export Citation:
Assignee:
TIANJIN INST OF PHARMACEUTICAL RES CO LTD (CN)
International Classes:
C07D249/12; A61K31/4196; A61P19/06; C07D249/08
Domestic Patent References:
| WO2010028190A2 | 2010-03-11 | |||
| WO2010135530A2 | 2010-11-25 | |||
| WO2009070740A2 | 2009-06-04 |
Other References:
DATABASE CAS 4 October 2013 (2013-10-04), retrieved from STN Database accession no. 1454/.53.5300
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
北京泛华伟业知识产权代理有限公司 (CN)
北京泛华伟业知识产权代理有限公司 (CN)
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