Title:
CARDIAC INDUCED PLURIPOTENT STEM CELLS AND METHODS OF USE IN REPAIR AND REGENERATION OF MYOCARDIUM
Document Type and Number:
WIPO Patent Application WO/2012/051515
Kind Code:
A3
Abstract:
Cardiac myocyte differentiation reported thus far is from iPS cells generated from mice and human fibroblasts. iPS cells from cardiac or ventricular specific cell types are generated herein having the potential to repair and regenerate infarcted myocardium. The cells were transduced with four sternness factors and reprogrammed them into iPS cells. These cardiac iPS cells were able to differentiate into beating cardiac myocytes, formed cardiac-specific structures, and positively stained for cardiac specific proteins. Transplanted cells also significantly inhibited apoptosis and fibrosis and improved cardiac function.
Inventors:
SINGLA DINENDER (US)
Application Number:
PCT/US2011/056329
Publication Date:
June 28, 2012
Filing Date:
October 14, 2011
Export Citation:
Assignee:
UNIV CENTRAL FLORIDA RES FOUND (US)
SINGLA DINENDER (US)
SINGLA DINENDER (US)
International Classes:
A61K35/34; A61K35/545
Domestic Patent References:
| WO2010059806A2 | 2010-05-27 |
Foreign References:
| US20090186414A1 | 2009-07-23 | |||
| US20090246179A1 | 2009-10-01 | |||
| US20100068190A1 | 2010-03-18 |
Other References:
See also references of EP 2627342A4
Attorney, Agent or Firm:
LANIER, J., Gibson et al. (999 Peachtree Street Ne Suite 100, Atlanta GA, US)
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