Title:
A CARDIO MYOPEPTIDIN, THE PRODUCTION AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/108751
Kind Code:
A1
Abstract:
The present invention relates to a cardio myopeptidin which is isolated from the hearts of non-human healthy mammals. The molecular weight of the cardio myopeptidin is less than 10000 Dalton, the peptide content thereof being 75%∼90%, and the free amino acid content 6% ∼ 15%, the ribonucleic acid content less than 2%, the deoxyribonucleic acid content less than 7.5%. The present invention further provides a method of producing the cardio myopeptidin and the use thereof in producing pharmaceuticals for treating cardiac disorders, specifically the use in producing pharmaceuticals for treating myocardial ischemic and reperfusion injury; the cardio myopeptidin of the present invention can work directly on myocytes, promoting the repair of injuries caused by various reasons, and providing a new way to relieve ischemic and reperfusion injury, and to promot the repair of injuried myocardium.
Inventors:
CHEN YUSONG (CN)
LI SHU (CN)
LI SHU (CN)
Application Number:
PCT/CN2004/000138
Publication Date:
December 16, 2004
Filing Date:
February 23, 2004
Export Citation:
Assignee:
DALIAN ZHEN AO PHARMACEUTICAL (CN)
CHEN YUSONG (CN)
LI SHU (CN)
CHEN YUSONG (CN)
LI SHU (CN)
International Classes:
C07K2/00; C07K14/47; (IPC1-7): C07K2/00
Foreign References:
| CN1108663A | 1995-09-20 |
Other References:
ZHANG X.: "Studies on biochemical characters and effect on DNA synthesis of myocardial cells of heart active factor", PHARMACEUTICAL BIOTECHNOLOGY, vol. 3, no. 2, 1996, pages 98 - 100, XP008103428
YANG L. P. ET AL., CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 25, no. 6, June 2000 (2000-06-01), pages 362 - 363
YANG L. P. ET AL., CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 25, no. 6, June 2000 (2000-06-01), pages 362 - 363
Attorney, Agent or Firm:
BEIJING YUANZHONG INTELLECTUAL PROPERTY AGENT LTD. (Prestige Tower No.2 Building A-29
Beisanhuanzhong Roa, Xicheng District Beijing 9, CN)
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