Title:
CARDIOMYOCYTE PRODUCTION METHOD, VENTRICULAR CARDIOMYOCYTES AND PRODUCTION METHOD THEREFOR, AND SCREENING METHOD
Document Type and Number:
WIPO Patent Application WO/2016/056653
Kind Code:
A1
Abstract:
Provided are: a cardiomyocyte production method with which it is possible to produce high-quality cardiomyocytes; ventricular cardiomyocytes having high quality, reduced cardiomyocyte heterogeneity, and reduced contamination with non-cardiomyocytes, and a production method for said ventricular cardiomyocytes; and a method using cardiomyocytes and/or ventricular cardiomyocytes for screening preventive or therapeutic drugs that treat at least one of hypertrophic cardiomyopathy, cardiomegaly, and Noonan syndrome.
Inventors:
NAITO ATSUHIKO (JP)
KOMURO ISSEI (JP)
KOMURO ISSEI (JP)
Application Number:
PCT/JP2015/078784
Publication Date:
April 14, 2016
Filing Date:
October 09, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N5/077; C12N5/071; C12N5/074; C12N5/0775; C12N5/10; C12N15/09; C12N15/11; C12Q1/06
Domestic Patent References:
| WO2014078414A1 | 2014-05-22 | |||
| WO2013033133A1 | 2013-03-07 |
Foreign References:
| JP2013531497A | 2013-08-08 |
Other References:
BURRIDGE P. W. ET AL.: "Chemically defined generation of human cardiomyocytes", NATURE METHODS, vol. 11, no. 8, 15 June 2014 (2014-06-15), pages 855 - 860, XP055239845, doi:10.1038/nmeth.2999
QI X-Y. ET AL.: "Effects of Ginkgolide B on action potential and calcium, potassium current in guinea pig ventricular myocytes", ACTA PHARMACOL SIN., vol. 25, no. 2, February 2004 (2004-02-01), pages 203 - 207
OTSUJI T. G. ET AL.: "Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs", STEM CELL RESEARCH, vol. 4, pages 201 - 213, XP027054730
LIEU D. K. ET AL., CIRC ARRHYTHM ELECTROPHYSIOL., vol. 6, pages 191 - 201
VAIDYANATHAN S. ET AL.: "Detection and enumeration of circulating tumor cells using imaging flow cytometery", CANCER RES., vol. 74, Retrieved from the Internet [retrieved on 20151222]
QI X-Y. ET AL.: "Effects of Ginkgolide B on action potential and calcium, potassium current in guinea pig ventricular myocytes", ACTA PHARMACOL SIN., vol. 25, no. 2, February 2004 (2004-02-01), pages 203 - 207
OTSUJI T. G. ET AL.: "Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs", STEM CELL RESEARCH, vol. 4, pages 201 - 213, XP027054730
LIEU D. K. ET AL., CIRC ARRHYTHM ELECTROPHYSIOL., vol. 6, pages 191 - 201
VAIDYANATHAN S. ET AL.: "Detection and enumeration of circulating tumor cells using imaging flow cytometery", CANCER RES., vol. 74, Retrieved from the Internet
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Sumio Tanai (JP)
Sumio Tanai (JP)
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