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Patent Searching and Data


Title:
CARNITINE AND INOSITOL PHOSPHATE-CONTAINING COMPOSITION USEFUL AS DIETARY SUPPLEMENT OR DRUG
Document Type and Number:
WIPO Patent Application WO/2000/064426
Kind Code:
A2
Abstract:
A composition is disclosed suitable for the prevention and/or treatment of cardiovascular and neurocerebral disorders, tissue anoxic forms, muscular energy deficits, inflammatory-type abnormalitites, alterations of blood coagulation such as thrombosis, and tissue proliferation forms, that may take the form of a dietary supplement, dietetic support or of an actual medicine, which comprises as characterizing active ingredients: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; and (b) an inositol phosphate, particularly the inositol hexaphosphate (IP6).

Inventors:
CAVAZZA CLAUDIO (IT)
Application Number:
PCT/IT2000/000158
Publication Date:
November 02, 2000
Filing Date:
April 19, 2000
Export Citation:
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Assignee:
SIGMA TAU HEALTHSCIENCE SPA (IT)
CAVAZZA CLAUDIO (IT)
International Classes:
A61K9/02; A23L1/30; A61K9/10; A61K9/16; A61K9/20; A61K9/48; A61K31/00; A61K31/197; A61K31/205; A61K31/66; A61K31/6615; A61K31/70; A61K36/899; A61P3/02; A61P9/00; A61P25/00; (IPC1-7): A61K31/00
Domestic Patent References:
WO1998033494A11998-08-06
WO1998041113A21998-09-24
Attorney, Agent or Firm:
Cavattoni, Fabio (Viale dei Parioli 160, Roma, IT)
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Claims:
Claims
1. A combination composition which comprises: (a) propionyl Lcarnitine or a pharmacologically acceptable salt thereof ; and (b) an inositol phosphate.
2. The composition of claim 1, wherein the inositol phosphate is selected from the group consisting of inositol monophosphate, inositol tetraphosphate, inositol pentaphosphate and inositol hexaphosphate (IP6).
3. The composition of claim 1 or 2, wherein the ingredient (a) further comprises a"carnitine"selected from the group comprising Lcarnitine, acetyl Lcarnitine, butyryl Lcarnitine, valeryl Lcarnitine, isovaleryl Lcarnitine or their pharmacologically acceptable salts or mixtures thereo£.
4. The composition of claims 13, wherein ingredient (b) further comprises inositol.
5. The composition of claims 14, wherein the weight ratio (a): (b) is from 1: 10 to 1: 1.
6. The composition of any of the preceding claims, wherein the ingredient (b) occurs as a vegetable product or extract of vegetable products containing same.
7. The composition of claims 6, wherein the vegetal product is bran or brown rice and/or their extracts.
8. The composition of any of the preceding claims, wherein the pharmacologically acceptable salt of Lcarnitine or alkanoyl Lcarnitine is selected from the group comprising: chloride; bromide; iodide; aspartate, acid aspartate; citrate, acid citrate; tartrate; phosphate, acid phosphate; fumarate, acid fumarate; glycerophosphate; glucose phosphate; lactate; maleate, acid maleate; orotate; acid oxalate; sulphate, acid sulphate; trichloroacetate; trifluoroacetate and methane sulphonate.
9. The composition of any of the preceding claims, which further comprises vitamins, coenzymes, mineral substances and antioxidants.
10. The composition of any of the preceding claims, orally administrable, in the form of a dietary supplement.
11. The composition of any of the preceding claims 19, orally, parenterally, rectally or transdermally administrable in the form of a medicament.
12. The dietary supplement of claim 10, for the prevention of tissue anoxic forms, cardiac or nervous disturbances, muscular energy deficits, asthenia and fatigue, inflammatorytype abnormalities, and tissue proliferation forms.
13. The medicament of claim 11 for the therapeutic treatment of free radical inducedpathologies, for the treatment of cardiovascular or cerebral disorders due to tissue anoxia or ageing, alterations of blood coagulation such as thrombosis, inflammatorytype abnormalities, muscular energy deficits accompanied by asthenia and fatigue and as adjuvant in the treatment of tissue proliferation forms.
14. The dietary supplement of claim 12, in the form of tablets, pills, capsules, granulates or syrups.
15. The medicament of claim 13, in the form of tablets, pills, capsules, granulates, syrups, suppositories, vials or drops.
16. Use of a combination composition which comprises as character izing active ingredients: (a) propionyl Lcarnitine or a pharmacologically acceptable salt thereof; (b) an inositol phosphate selected from the group consisting of inositol monophosphate, inositol tetraphosphate, inositol penta phosphate and inositol hexaphosphate (IP6) for preparing a dietary supplement or medicament useful for the prevention and/or treatment of cardiovascular or neurocerebral disorders due to chronic or acute tissue anoxia, energy deficits, inflammatorytype abnormalities, nervous and muscular astheniae and of tissue proliferation forms.
17. The use of claim 16, wherein the ingredient (a) further comprises a"carnitine"selected from the group comprising Lcarnitine, acetyl Lcarnitine, butyryl Lcarnitine, valeryl Lcarnitine, isovaleryl L carnitine or their pharmacologically acceptable salts or mixtures thereof and the ingredient (b) further comprising inositol.
Description:
INTERNATIONALSEARCH REPORT Inter. nal Applicatlon No .. ; formation on patent family members PCT/IT 00/00158 Patent document Publication Patent family Publication cited in search report date member (s) date WO 9833494 A 06-08-1998 AU 6141498 A 25-08-1998 EP 1021177 A 26-07-2000 EP 1021177 A 26-07-2000 WO 9841113 A 24-09-1998 IT RM970155 A 21-09-1998 AU 6635398 A 12-10-1998 CN 1250352 T 12-04-2000 EP 0971600 A 19-01-2000 PL 335649 A 08-05-2000 US 6063820 A 16-05-2000