Title:
CAROTENOID-CONTAINING COGNITIVE FUNCTION IMPROVING COMPOSITION FOR USE IN EXERCISE THERAPY FOR COGNITIVE FUNCTION IMPROVEMENT
Document Type and Number:
WIPO Patent Application WO/2017/213197
Kind Code:
A1
Abstract:
The present invention pertains to a carotenoid-containing composition for use in an exercise therapy for cognitive function improvement, particularly, in an exercise therapy for neogenesis of hippocampal neurons.
Inventors:
SOYA HIDEAKI (JP)
YOOK JANGSOO (JP)
YOOK JANGSOO (JP)
Application Number:
PCT/JP2017/021203
Publication Date:
December 14, 2017
Filing Date:
June 07, 2017
Export Citation:
Assignee:
ASTAREAL CO LTD (JP)
UNIV TSUKUBA (JP)
UNIV TSUKUBA (JP)
International Classes:
A61K31/015; A23L33/10; A61K31/122; A61K36/05
Foreign References:
JP2007126455A | 2007-05-24 | |||
JP2006116161A | 2006-05-11 | |||
JPH08103288A | 1996-04-23 | |||
JPH0568585A | 1993-03-23 |
Other References:
JANGSOO YOOK ET AL.: "Tennen Yurai Supplement to Kaiba no Kino Sokushin", TAIIKU NO KAGAKU, vol. 65, no. 1, 1 January 2015 (2015-01-01), pages 21 - 27, XP009515023, ISSN: 0039-8985
YOOK ET AL.: "Astaxanthin supplementation enhances adult hippocampal neurogenesis and spatial memory in mice", MOLECULAR NUTRITION AND FOOD RESEARCH, vol. 60, no. 3, 7 January 2016 (2016-01-07), pages 589 - 599, XP055599177, ISSN: 1613-4133
See also references of EP 3470066A4
KIM J. H.; NAM S.W.; KIM B, W.; CHOI W. ET AL.: "Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells", INT. J. MOL. SCI., vol. 11, 2010, pages 5109 - 5119
LU Y.; XIE T.; HE X. X.; MAO Z. F. ET AL.: "Astaxanthin rescues neuron loss and attenuates oxidative stress induced by amygdala kindling in adult rat hippocampus", NEUROSCI. LETT., vol. 597, 2015, pages 49 - 53
ERICKSON KI; VOSS MW; PRAKASH RS; BASAK C; SZABO A; CHADDOCK L; KIM JS; HEO S; ALVES H; WHITE SM: "Exercise training increases size of hippocampus and improves memory", PROC NATL ACAD SCI USA, vol. 108, 2011, pages 3017 - 3022
BYUN K; HYODO K; SUWABE K; OCHI G; SAKAIRI Y; KATO M; DAN I, SOYA: "Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: an fNIRS study", NEUROIMAGE, vol. 98, 2014, pages 336 - 345
BEAVER WL; WASSERMAN K; WHIPP BJ.: "A New Method for Detecting Anaerobic Threshold by Gas-Exchange", J APPL PHYSIOL, vol. 60, 1986, pages 2020 - 2027
MATEIKA JH; DUFFIN J.: "Ventilatory responses to exercise performed below and above the first ventilatory treshold", EUR J APPL PHYSIOL OCCUP PHYSIOL, vol. 68, 1994, pages 327 - 335
SOYA H; MUKAI A; DEOCARIS CC; OHIWA N; CHANG H; NISHIJIMA T; FUJIKAWA T; TOGASHI K; SAI TO T: "Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model", NEUROSCI RES, vol. 58, 2007, pages 341 - 348, XP022188779, DOI: doi:10.1016/j.neures.2007.04.004
INOUE K; HANAOKA Y; NISHIJIMA T; OKAMOTO M; CHANG H; SAITO T; SOYA H: "Long-term mild exercise training enhances hippocampus-dependent memory in rats", INT J SPORTS MED, vol. 36, 2015, pages 280 - 285
INOUE K; OKAMOTO M; SHIBATO J; LEE MC; MATSUI T; RAKWAL R; SOYA H: "Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus", PLOS ONE, vol. 10, 2015, pages e0133089
POP V; HEAD E; HILL MA; GILLEN D; BERCHTOLD NC; MUGGENBURG BA; MILGRAM NW; MURPHY MP; COTMAN CW: "Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines", J NEUROSCI, vol. 30, 2010, pages 9831 - 9839
HIRANO M; RAKWAL R; SHIBATO J; SAWA H; NAGASHIMA K; OGAWA Y; YOSHIDA Y; IWAHASHI H; NIKI E; MASUO Y: "Proteomics- and transcriptomics-based screening of differentially expressed proteins and genes in brain of Wig rat: a model for attention deficit hyperactivity disorder (ADHD) research", J PROTEOME RES, vol. 7, 2008, pages 2471 - 2489
LU M; GROVE EA; MILLER RJ: "Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor", PROC NATL ACAD SCI USA, vol. 99, 2002, pages 7090 - 7095
KOLODZIEJ A; SCHULZ S; GUYON A; WU DF; PFEIFFER M; ODEMIS V; HOLLT V; STUMM R: "Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus", J NEUROSCI, vol. 28, 2008, pages 4488 - 4500
CHALASANI SH; BARIBAUD F; COUGHLAN CM; SUNSHINE MJ; LEE VM; DOMS RW; LITTMAN DR; RAPER JA: "The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal 2003; Floridi F, Trettel F, Di Bartolomeo S, Ciotti MT, Limatola C. Signalling palthways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells", J NEUROIMMUNOL, vol. 135, 2003, pages 38 - 46
GARZA JC; GUO M; ZHANG W; LU XY: "Leptin increases adult hippocampal neurogenesis in vivo and in vitro", J BIOL CHEM, vol. 283, 2008, pages 18238 - 18247
LI XL; AOU S; OOMURA Y; HORI N; FUKUNAGA K; HORI T: "Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents", NEUROSCIENCE, vol. 113, 2002, pages 607 - 615
HARVEY J: "Leptin regulation of neuronal excitability and cognitive function", CURR OPIN PHARMACOL, vol. 7, 2007, pages 643 - 647, XP022371182, DOI: doi:10.1016/j.coph.2007.10.006
GUO Z; JIANG H; XU X; DUAN W; MATTSON MP: "Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization", J BIOL CHEM, vol. 283, 2008, pages 1754 - 1763
LAMMERS R; GRAY A; SCHLESSINGER J; ULLRICH A: "Differential signalling potential of insulin-and IGF-1-receptor cytoplasmic domains", EMBO J, vol. 8, 1989, pages 1369 - 1375
TREJO JL; CARRO E; TORRES-ALEMAN I: "Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus", J NEUROSCI, vol. 21, 2001, pages 1628 - 1634
SONNTAG WE; RAMSEY M; CARTER CS: "Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging", AGEING RES REV, vol. 4, 2005, pages 195 - 212
YOOK ET AL.: "Astaxanthin supplementation enhances adult hippocampal neurogenesis and spatial memory in mice", MOLECULAR NUTRITION AND FOOD RESEARCH, vol. 60, no. 3, 7 January 2016 (2016-01-07), pages 589 - 599, XP055599177, ISSN: 1613-4133
See also references of EP 3470066A4
KIM J. H.; NAM S.W.; KIM B, W.; CHOI W. ET AL.: "Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells", INT. J. MOL. SCI., vol. 11, 2010, pages 5109 - 5119
LU Y.; XIE T.; HE X. X.; MAO Z. F. ET AL.: "Astaxanthin rescues neuron loss and attenuates oxidative stress induced by amygdala kindling in adult rat hippocampus", NEUROSCI. LETT., vol. 597, 2015, pages 49 - 53
ERICKSON KI; VOSS MW; PRAKASH RS; BASAK C; SZABO A; CHADDOCK L; KIM JS; HEO S; ALVES H; WHITE SM: "Exercise training increases size of hippocampus and improves memory", PROC NATL ACAD SCI USA, vol. 108, 2011, pages 3017 - 3022
BYUN K; HYODO K; SUWABE K; OCHI G; SAKAIRI Y; KATO M; DAN I, SOYA: "Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: an fNIRS study", NEUROIMAGE, vol. 98, 2014, pages 336 - 345
BEAVER WL; WASSERMAN K; WHIPP BJ.: "A New Method for Detecting Anaerobic Threshold by Gas-Exchange", J APPL PHYSIOL, vol. 60, 1986, pages 2020 - 2027
MATEIKA JH; DUFFIN J.: "Ventilatory responses to exercise performed below and above the first ventilatory treshold", EUR J APPL PHYSIOL OCCUP PHYSIOL, vol. 68, 1994, pages 327 - 335
SOYA H; MUKAI A; DEOCARIS CC; OHIWA N; CHANG H; NISHIJIMA T; FUJIKAWA T; TOGASHI K; SAI TO T: "Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model", NEUROSCI RES, vol. 58, 2007, pages 341 - 348, XP022188779, DOI: doi:10.1016/j.neures.2007.04.004
INOUE K; HANAOKA Y; NISHIJIMA T; OKAMOTO M; CHANG H; SAITO T; SOYA H: "Long-term mild exercise training enhances hippocampus-dependent memory in rats", INT J SPORTS MED, vol. 36, 2015, pages 280 - 285
INOUE K; OKAMOTO M; SHIBATO J; LEE MC; MATSUI T; RAKWAL R; SOYA H: "Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus", PLOS ONE, vol. 10, 2015, pages e0133089
POP V; HEAD E; HILL MA; GILLEN D; BERCHTOLD NC; MUGGENBURG BA; MILGRAM NW; MURPHY MP; COTMAN CW: "Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines", J NEUROSCI, vol. 30, 2010, pages 9831 - 9839
HIRANO M; RAKWAL R; SHIBATO J; SAWA H; NAGASHIMA K; OGAWA Y; YOSHIDA Y; IWAHASHI H; NIKI E; MASUO Y: "Proteomics- and transcriptomics-based screening of differentially expressed proteins and genes in brain of Wig rat: a model for attention deficit hyperactivity disorder (ADHD) research", J PROTEOME RES, vol. 7, 2008, pages 2471 - 2489
LU M; GROVE EA; MILLER RJ: "Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor", PROC NATL ACAD SCI USA, vol. 99, 2002, pages 7090 - 7095
KOLODZIEJ A; SCHULZ S; GUYON A; WU DF; PFEIFFER M; ODEMIS V; HOLLT V; STUMM R: "Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus", J NEUROSCI, vol. 28, 2008, pages 4488 - 4500
CHALASANI SH; BARIBAUD F; COUGHLAN CM; SUNSHINE MJ; LEE VM; DOMS RW; LITTMAN DR; RAPER JA: "The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal 2003; Floridi F, Trettel F, Di Bartolomeo S, Ciotti MT, Limatola C. Signalling palthways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells", J NEUROIMMUNOL, vol. 135, 2003, pages 38 - 46
GARZA JC; GUO M; ZHANG W; LU XY: "Leptin increases adult hippocampal neurogenesis in vivo and in vitro", J BIOL CHEM, vol. 283, 2008, pages 18238 - 18247
LI XL; AOU S; OOMURA Y; HORI N; FUKUNAGA K; HORI T: "Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents", NEUROSCIENCE, vol. 113, 2002, pages 607 - 615
HARVEY J: "Leptin regulation of neuronal excitability and cognitive function", CURR OPIN PHARMACOL, vol. 7, 2007, pages 643 - 647, XP022371182, DOI: doi:10.1016/j.coph.2007.10.006
GUO Z; JIANG H; XU X; DUAN W; MATTSON MP: "Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization", J BIOL CHEM, vol. 283, 2008, pages 1754 - 1763
LAMMERS R; GRAY A; SCHLESSINGER J; ULLRICH A: "Differential signalling potential of insulin-and IGF-1-receptor cytoplasmic domains", EMBO J, vol. 8, 1989, pages 1369 - 1375
TREJO JL; CARRO E; TORRES-ALEMAN I: "Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus", J NEUROSCI, vol. 21, 2001, pages 1628 - 1634
SONNTAG WE; RAMSEY M; CARTER CS: "Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging", AGEING RES REV, vol. 4, 2005, pages 195 - 212
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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