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Title:
CARRIER COMPOUND FOR LIQUID PHASE SYNTHESIS OF POLYPEPTIDE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/127919
Kind Code:
A1
Abstract:
The present invention relates to a carrier compound for liquid phase synthesis of a polypeptide, a preparation method therefor and use thereof, and specifically discloses a fused ring compound which can be used as a liquid phase carrier of the polypeptide. The fused ring compound is represented by formula (A) or (B), wherein X is selected from H, F, Cl, Br, I or a group bearing hydroxy, amino, carboxy, or halogen, and Y is selected from H, F, Cl, Br or I. The liquid phase synthesis carrier compound of the present invention is simple to prepare and has high reaction efficiency.

Inventors:
YE, Silei (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
CHEN, Xinliang (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
MI, Pengcheng (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
TAO, Anjin (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
YUAN, Jiancheng (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
Application Number:
CN2018/079276
Publication Date:
July 04, 2019
Filing Date:
March 16, 2018
Export Citation:
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Assignee:
HYBIO PHARMACEUTICAL CO., LTD. (4th floor, Hybio Medicine Park Office BuildingHigh-tech Industrial Park Central District, Nansha, Shenzhen Guangdong 7, 518057, CN)
International Classes:
C07C13/62; C07K7/16
Foreign References:
CN101693738A2010-04-14
CN105367627A2016-03-02
Other References:
LI, YONGZHEN ET AL.: "Progress in Synthesis and Applications of Polypeptides", CHEMISTRY & BIOENGINEERING, vol. 27, no. 4, 31 December 2010 (2010-12-31), pages 9 - 14
HAN, XIANG ET AL.: "Application of Solid-Phase Peptides Synthesis", PROGRESS IN PHARMACEUTICAL SCIENCES - OVERVIEW AND MONOGRAPH, vol. 28, no. 1, 31 December 2004 (2004-12-31), pages 10 - 14
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (905 Tower2,, No.99 Chaoyang North Road Chaoyang District, Beijing 3, 100123, CN)
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