Title:
CARRIER FOR DELIVERING DRUG TO BRAIN, AND COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/207864
Kind Code:
A1
Abstract:
The present invention provides: a micelle having an improved micelle forming ability; and a composition for delivering a drug to the brain, which contains the micelle. More specifically, the present invention provides: a micelle of which the outer surface is modified with a first polymer and a second polymer, wherein the first polymer is polyethylene glycol having a number average molecular weight of 4000 Da or more, the second polymer is polyethylene glycol having a number average molecular weight of 3000 Da or less, and the first polymer is modified with a GLUT1 ligand and consequently the outer surface of the carrier is modified with the GLUT1 ligand; and a composition for delivering a drug to the brain, which contains the micelle.
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Inventors:
KATAOKA KAZUNORI (JP)
ANRAKU YASUTAKA (JP)
NAKAMURA NORIKO (JP)
ANRAKU YASUTAKA (JP)
NAKAMURA NORIKO (JP)
Application Number:
PCT/JP2018/018073
Publication Date:
November 15, 2018
Filing Date:
May 10, 2018
Export Citation:
Assignee:
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
International Classes:
A61K47/10; A61K9/107; A61K31/7088; A61K39/395; A61K45/00; A61K47/26; A61K47/69; A61K48/00; A61K49/00; A61P25/00
Domestic Patent References:
| WO2017002979A1 | 2017-01-05 | |||
| WO2015075942A1 | 2015-05-28 |
Other References:
ISHII, T. ET AL.: "Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths", CHEM. COMMUN., vol. 52, 2016, pages 1517 - 1519, XP055563178
NAKAMURA, NORIKO ET AL.: "Evaluation on target recognition ability of ligand molecule on polymer micelle outer layer, aiming for blood brain barrier breakthrough", PROCEEDINGS OF THE 39TH CONFERENCE OF JAPANESE SOCIETY FOR BIOMATERIALS, 13 November 2017 (2017-11-13), pages 183
SAWANT, R. R. ET AL.: "The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells", J. DRUG TARGET., vol. 16, no. 7, 2008, pages 596 - 600
UCHIDA, K. ET AL.: "A Reactive Poly(ethylene glycol) Layer To Achieve Specific Surface Plasmon Resonance Sensing with a High S/N Ratio: The Substantial Role of a Short Underbrushed PEG Layer in Minimizing Nonspecific Absorption", ANAL. CHEM., vol. 77, no. 4, 2005, pages 1075 - 1080, XP055079886
NAKAMURA, NORIKO ET AL.: "Evaluation on target recognition ability of ligand molecule on polymer micelle outer layer, aiming for blood brain barrier breakthrough", PROCEEDINGS OF THE 39TH CONFERENCE OF JAPANESE SOCIETY FOR BIOMATERIALS, 13 November 2017 (2017-11-13), pages 183
SAWANT, R. R. ET AL.: "The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells", J. DRUG TARGET., vol. 16, no. 7, 2008, pages 596 - 600
UCHIDA, K. ET AL.: "A Reactive Poly(ethylene glycol) Layer To Achieve Specific Surface Plasmon Resonance Sensing with a High S/N Ratio: The Substantial Role of a Short Underbrushed PEG Layer in Minimizing Nonspecific Absorption", ANAL. CHEM., vol. 77, no. 4, 2005, pages 1075 - 1080, XP055079886
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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