Title:
CARRIER FOR DRUG DELIVERY AND CONJUGATE, COMPOSITION CONTAINING SAME, AND METHOD FOR ADMINISTERING SAME
Document Type and Number:
WIPO Patent Application WO/2015/075942
Kind Code:
A1
Abstract:
The present invention provides a vesicle for delivering a drug to the brain, a conjugate, a composition containing same, and a method for administering same. A composition for administration to a subject according to a dosing regimen, the composition containing a carrier for drug delivery, wherein the dosing regimen includes the administration of the composition to a subject who has been made to fast or in whom hypoglycemia has been induced and the induction of a rise in blood sugar levels in the subject, and the outer surface of the carrier in the composition is modified by a GLUT1 ligand.
Inventors:
KATAOKA KAZUNORI (JP)
ANRAKU YASUTAKA (JP)
NISHIYAMA NOBUHIRO (JP)
MIYATA KANJIRO (JP)
ISHII TAKEHIKO (JP)
MATSUMOTO YU (JP)
FUKUSATO YU (JP)
MIZOGUCHI AKIHIRO (JP)
YOKOTA TAKANORI (JP)
KUWAHARA HIROYA (JP)
NISHINA KAZUTAKA (JP)
MIZUSAWA HIDEHIRO (JP)
ANRAKU YASUTAKA (JP)
NISHIYAMA NOBUHIRO (JP)
MIYATA KANJIRO (JP)
ISHII TAKEHIKO (JP)
MATSUMOTO YU (JP)
FUKUSATO YU (JP)
MIZOGUCHI AKIHIRO (JP)
YOKOTA TAKANORI (JP)
KUWAHARA HIROYA (JP)
NISHINA KAZUTAKA (JP)
MIZUSAWA HIDEHIRO (JP)
Application Number:
PCT/JP2014/005856
Publication Date:
May 28, 2015
Filing Date:
November 21, 2014
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV TOKYO MEDICAL & DENTAL (JP)
UNIV TOKYO MEDICAL & DENTAL (JP)
International Classes:
A61K9/127; A61K31/7088; A61K39/395; A61K47/34; A61K47/48; A61K49/00; A61P25/00; A61P43/00; B01J13/00; C08L77/00
Domestic Patent References:
| WO2011145745A1 | 2011-11-24 | |||
| WO2007068429A1 | 2007-06-21 |
Other References:
QU B. ET AL.: "Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 72, 20 November 2013 (2013-11-20), pages 110 - 118, XP028829440
KAWAMURA ET AL.: "Size to Ligand Donyuritsu no Chosei ga Kano na Polyion Complex-gata Vesicle (PICsome) no Kochiku to Kino Hyoka", POLYMER PREPRINTS, JAPAN, vol. 62, no. 2, 28 August 2013 (2013-08-28), pages 4823 - 4824, XP008183316
SIMPSON IA. ET AL.: "Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited.", JOURNAL OF NEUROCHEMISTRY, vol. 72, 1999, pages 238 - 247, XP055344756
CARBOHYDR. RES., vol. 19, 1971, pages 197 - 210
DRUG METABOLISM AND DISPOSITION, vol. 27, no. 12, 1999, pages 1406 - 1414
See also references of EP 3072506A4
KAWAMURA ET AL.: "Size to Ligand Donyuritsu no Chosei ga Kano na Polyion Complex-gata Vesicle (PICsome) no Kochiku to Kino Hyoka", POLYMER PREPRINTS, JAPAN, vol. 62, no. 2, 28 August 2013 (2013-08-28), pages 4823 - 4824, XP008183316
SIMPSON IA. ET AL.: "Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited.", JOURNAL OF NEUROCHEMISTRY, vol. 72, 1999, pages 238 - 247, XP055344756
CARBOHYDR. RES., vol. 19, 1971, pages 197 - 210
DRUG METABOLISM AND DISPOSITION, vol. 27, no. 12, 1999, pages 1406 - 1414
See also references of EP 3072506A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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