Title:
CARRIER FOR DRUG DELIVERY USE
Document Type and Number:
WIPO Patent Application WO/2019/225296
Kind Code:
A1
Abstract:
A carrier for drug delivery use, comprising a human serum albumin variant in which a mannose-rich sugar chain having 8 or more mannose residues is bonded to a substance capable of interacting with the mannose-rich sugar chain or a binding site in the substance capable of interacting with the mannose-rich sugar chain.
Inventors:
MARUYAMA TORU (JP)
WATANABE HIROSHI (JP)
ISHIMA YU (JP)
MAEDA HITOSHI (JP)
MIZUTA YUKI (JP)
KINOSHITA RYO (JP)
WATANABE HIROSHI (JP)
ISHIMA YU (JP)
MAEDA HITOSHI (JP)
MIZUTA YUKI (JP)
KINOSHITA RYO (JP)
Application Number:
PCT/JP2019/017921
Publication Date:
November 28, 2019
Filing Date:
April 26, 2019
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
C12N15/62; A61K47/64; A61K47/68; A61K49/04; A61K49/16; A61K51/10; A61P35/00; C07K14/765; C07K19/00; C07K16/00
Foreign References:
| JP2008043285A | 2008-02-28 | |||
| JP2008538506A | 2008-10-30 |
Other References:
MINAYOSHI, YUKI ET AL.: "Design and hepatoprotective effect of liver Kupffer cell targeting-type interferon a2b in which recombinant high mannose-added albumin serves as a carrier", PROGRAMS AND ABSTRACTS OF THE 32ND ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 1 June 2016 (2016-06-01)
FUJITA, T. ET AL.: "Control of in vivo fate of albumin derivatives utilizing combined chemical modification", J. DRUG. TARGET., vol. 2, no. 2, 1994, pages 157 - 165
DOSIO, F. ET AL.: "Poly(ethylene glycol)-human serum albumin-paclitaxel conjugates: preparation, characterization and pharmacokinetics", J. CONTROL. RELEASE, vol. 76, 11 September 2001 (2001-09-11), pages 107 - 117, XP004302042, DOI: 10.1016/S0168-3659(01)00420-5
SETT, R. ET AL.: "Pharmacokinetics and biodistribution of methotrexate conjugated to mannosyl human serum albumin", J . ANTIMICROB. CHEMOTHER., vol. 31, no. 1, January 1993 (1993-01-01), pages 151 - 159, XP055655424
MIZUTA, YUKI ET AL.: "Development of novel DDS carrier targeting tumor- associated macrophages", PROGRAMS AND ABSTRACTS OF THE 34ND ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 28 May 2018 (2018-05-28), pages 147
FUJITA, T. ET AL.: "Control of in vivo fate of albumin derivatives utilizing combined chemical modification", J. DRUG. TARGET., vol. 2, no. 2, 1994, pages 157 - 165
DOSIO, F. ET AL.: "Poly(ethylene glycol)-human serum albumin-paclitaxel conjugates: preparation, characterization and pharmacokinetics", J. CONTROL. RELEASE, vol. 76, 11 September 2001 (2001-09-11), pages 107 - 117, XP004302042, DOI: 10.1016/S0168-3659(01)00420-5
SETT, R. ET AL.: "Pharmacokinetics and biodistribution of methotrexate conjugated to mannosyl human serum albumin", J . ANTIMICROB. CHEMOTHER., vol. 31, no. 1, January 1993 (1993-01-01), pages 151 - 159, XP055655424
MIZUTA, YUKI ET AL.: "Development of novel DDS carrier targeting tumor- associated macrophages", PROGRAMS AND ABSTRACTS OF THE 34ND ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 28 May 2018 (2018-05-28), pages 147
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Download PDF: