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Title:
CARRIER FOR INTRACELLULAR DELIVERY OF FUNCTIONAL PROTEIN
Document Type and Number:
WIPO Patent Application WO/2013/140643
Kind Code:
A1
Abstract:
A liposome for rapid, ready intracellular delivery of a functional protein, in particular a high-molecular-weight protein; the liposome having a lipid membrane which includes, as constituent lipids of the lipid membrane, a lipid in which polyarginine peptides comprising four to 20 consecutive arginine residues are covalently bound, as well as a lipid in which GALA peptides comprising an amino acid sequence represented by SEQ ID NO: 1 and/or R-GALA peptides comprising an amino acid sequence represented by SEQ ID NO: 2 are covalently bound, the protein meant for intracellular delivery being non-covalently bound to the outer surface of the lipid membrane.

Inventors:
HARASHIMA HIDEYOSHI (JP)
YAMADA YUMA (JP)
PEREZ SANDRA MILENA VERGARA (JP)
YASUZAKI YUKARI (JP)
Application Number:
PCT/JP2012/073938
Publication Date:
September 26, 2013
Filing Date:
September 19, 2012
Export Citation:
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Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K38/00; A61K9/127; A61K39/395; A61K47/42; A61K47/44; C07K7/00; C07K14/00; C12N1/38; C12N5/07
Domestic Patent References:
WO2008105178A12008-09-04
Other References:
FURUHATA,M. ET AL.: "Intracellular delivery of proteins in complexes with oligoarginine- modified liposomes and the effect of oligoarginine length", BIOCONJUG CHEM, vol. 17, no. 4, 2006, pages 935 - 942
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
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