Title:
CARRIER FOR TARGETING NERVE CELLS
Document Type and Number:
WIPO Patent Application WO2006114308
Kind Code:
A8
Abstract:
The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.
Inventors:
RUMMEL ANDREAS (DE)
WEIL TANJA (DE)
GUTCAITS ALEKSANDRS (LV)
WEIL TANJA (DE)
GUTCAITS ALEKSANDRS (LV)
Application Number:
PCT/EP2006/003896
Publication Date:
January 03, 2008
Filing Date:
April 26, 2006
Export Citation:
Assignee:
TOXOGEN GMBH (DE)
MERZ PHARMA GMBH & CO KGAA (DE)
RUMMEL ANDREAS (DE)
WEIL TANJA (DE)
GUTCAITS ALEKSANDRS (LV)
MERZ PHARMA GMBH & CO KGAA (DE)
RUMMEL ANDREAS (DE)
WEIL TANJA (DE)
GUTCAITS ALEKSANDRS (LV)
International Classes:
C07K14/195; A61K38/00; C07K14/33
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