Title:
CARTILAGE REGENERATION COMPOSITION CONTAINING HAPLN1 AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/045451
Kind Code:
A1
Abstract:
The present invention relates to a cartilage regeneration composition containing HAPLN1 as an active ingredient, and according to the present invention, HAPLN1 protein can stimulate cartilage formation and joint cartilage regeneration, and can increase the expression level of TGF-β receptor I of cartilage cells to increase the component ratio of cells that can form cartilage and induce regeneration of cartilaginous tissue. Therefore, HAPLN1 protein according to the present invention is a novel composition for controlling TGF-β signal transmission and can be effectively used as a pharmaceutical composition, health food, and a reagent composition for cartilage regeneration.
Inventors:
KIM DAE KYONG (KR)
JANG JI MIN (KR)
JANG JI MIN (KR)
Application Number:
PCT/KR2018/009996
Publication Date:
March 07, 2019
Filing Date:
August 29, 2018
Export Citation:
Assignee:
CHUNG ANG UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION (KR)
International Classes:
A61K31/728; A23L33/10; A61K38/14
Domestic Patent References:
| WO2017123951A1 | 2017-07-20 | |||
| WO2014130411A1 | 2014-08-28 |
Foreign References:
| US20160220699A1 | 2016-08-04 | |||
| KR20170031060A | 2017-03-20 | |||
| US20120171171A1 | 2012-07-05 | |||
| JP5767591B2 | 2015-08-19 |
Other References:
URANO, T. ET AL.: "Single-nucleotide Polymorphism in the Hyaluromm and Proteoglycan Link Protein 1 (HAPLN1) Gene Is Associated with Spinal Osteophyte Formation and Disc Degeneration in Japanese Women", EUROPEAN SPINE JOURNAL, vol. 20, no. 4, 2011, pages 572 - 577, XP019891028, DOI: doi:10.1007/s00586-010-1598-0
CHENG, T. ET AL.: "Comparison of Gene Expression Patterns in Articular Cartilage and Dedifferentiated Articular Chondrocytes", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 30, no. 2, 2012, pages 234 - 245, XP055580770, ISSN: 0736-0266, DOI: 10.1002/jor.21503
See also references of EP 3677269A4
CHENG, T. ET AL.: "Comparison of Gene Expression Patterns in Articular Cartilage and Dedifferentiated Articular Chondrocytes", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 30, no. 2, 2012, pages 234 - 245, XP055580770, ISSN: 0736-0266, DOI: 10.1002/jor.21503
See also references of EP 3677269A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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