Title:
CAS PROTEIN HAVING IMPROVED ACTIVITY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/174249
Kind Code:
A1
Abstract:
Provided are a Cas mutant protein and a polynucleotide encoding same; a fusion protein, a CRISPR-Cas system, a composition, an activated CRISPR complex, a host cell and a kit which contain the Cas mutant protein; and the use thereof in gene editing, gene targeting or gene cleavage.
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Inventors:
DUAN ZHIQIANG (CN)
Application Number:
PCT/CN2023/081273
Publication Date:
September 21, 2023
Filing Date:
March 14, 2023
Export Citation:
Assignee:
SHANDONG SHUNFENG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N9/22; C12N15/113; C12N15/55; C12N15/85
Domestic Patent References:
| WO2020088450A1 | 2020-05-07 |
Foreign References:
| CN111757889A | 2020-10-09 | |||
| CN112041444A | 2020-12-04 | |||
| CN112195164A | 2021-01-08 | |||
| CN113106081A | 2021-07-13 | |||
| CN113136375A | 2021-07-20 | |||
| CN111690773A | 2020-09-22 |
Other References:
XU XIAOSHU; CHEMPARATHY AUGUSTINE; ZENG LEIPING; KEMPTON HANNAH R.; SHANG STEPHEN; NAKAMURA MUNEAKI; QI LEI S.: "Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 81, no. 20, 3 September 2021 (2021-09-03), AMSTERDAM, NL, pages 4333, XP086833228, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2021.08.008
Attorney, Agent or Firm:
BEIJING BEVON INTELLECTUAL PROPERTY AGENCY (CN)
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