Title:
A CASPASE ACTIVATED PROTEIN KINASE
Document Type and Number:
WIPO Patent Application WO2000049139
Kind Code:
A3
Abstract:
A novel Ste20-related protein kinase, called SMAK, and methods for its preparation and use are provided. Nucleic acids encoding SMAK and methods for their use in preparing SMAK as well as in preparing and identifying SMAK analogs are provided.
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Inventors:
RUDNICKI MICHAEL A (CA)
SABOURIN LUC A (CA)
SABOURIN LUC A (CA)
Application Number:
PCT/CA2000/000165
Publication Date:
January 25, 2001
Filing Date:
February 18, 2000
Export Citation:
Assignee:
UNIV MCMASTER (CA)
RUDNICKI MICHAEL A (CA)
SABOURIN LUC A (CA)
RUDNICKI MICHAEL A (CA)
SABOURIN LUC A (CA)
International Classes:
C07K16/40; C12N9/12; (IPC1-7): C12N9/12; A61K38/17; A61P35/00; C07K16/40; C12N15/11; C12N15/54; C12N15/63; G01N33/53
Domestic Patent References:
| WO1997042212A1 | 1997-11-13 | |||
| WO1999029857A1 | 1999-06-17 | |||
| WO1999032637A1 | 1999-07-01 | |||
| WO1999053036A2 | 1999-10-21 |
Other References:
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 17 January 1998 (1998-01-17), HINXTON, GB, XP002144032
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 22 May 1997 (1997-05-22), HINXTON, GB, XP002144033
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 18 April 1997 (1997-04-18), HINXTON, GB, XP002144034
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 30 March 1998 (1998-03-30), HINXTON, GB, XP002144054
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 15 January 1997 (1997-01-15), HINXTON, GB, XP002144055
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 February 1997 (1997-02-01), HINXTON, GB, XP002144035
KURAMOCHI ET AL: "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 36, 5 September 1997 (1997-09-05), pages 22679 - 22684-22684, XP002132505, ISSN: 0021-9258
CREASY C L ET AL: "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 167, no. 1, 1995, pages 303 - 306, XP004043060, ISSN: 0378-1119
SCHAAR D G ET AL: "THE IDENTIFICATION OF A NOVEL CDNA PREFERENTIALLY EXPRESSED IN THE OLFACTORY-LIMBIC SYSTEM OF THE ADULT RAT", BRAIN RESEARCH,NL,AMSTERDAM, vol. 721, 30 January 1996 (1996-01-30), pages 217 - 228, XP000881673, ISSN: 0006-8993
GRAVES JONATHAN D ET AL: "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 8, 15 April 1998 (1998-04-15), pages 2224 - 2234, XP002144036, ISSN: 0261-4189
SCHINKMANN ET AL: "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 45, 7 November 1997 (1997-11-07), pages 28695 - 28703, XP002086764, ISSN: 0021-9258
SUSUMU ITOH ET AL: "Molecular cloning and characterization of a novel putative STE20-like kinase in Guinea pigs", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,US,NEW YORK, US, vol. 340, no. 2, 15 April 1997 (1997-04-15), pages 201 - 207, XP002079735, ISSN: 0003-9861
ICHIJO HIDENORI ET AL: "Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.", SCIENCE (WASHINGTON D C), vol. 275, no. 5296, 1997, pages 90 - 94, XP000933551, ISSN: 0036-8075
FANGER G R ET AL: "MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?", CURRENT OPINION IN GENETICS & DEVELOPMENT,XX,CURRENT BIOLOGY LTD, vol. 7, February 1997 (1997-02-01), pages 67 - 74, XP000867511, ISSN: 0959-437X
NOBES CATHERINE D ET AL: "Rho, Rac, and Cdc42 GTPases Regulate the Assembly of Multimolecular Focal Complexes Associated with Actin Stress Fibers, Lamellipodia, and Filopodia.", CELL, vol. 81, no. 1, 1995, pages 53 - 62, XP000929500, ISSN: 0092-8674
MANSER EDWARD ET AL: "Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 3, 1997, pages 1129 - 1143, XP002144038, ISSN: 0270-7306
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 July 1997 (1997-07-01), HINXTON, GB, XP002144039
KURAMOCHI S ET AL: "MOLECULAR CLONING OF THE HUMAN GENE STK10 ENCODING LYMPHOCYTE- ORIENTED KINASE, AND COMPARITIVE CHROMOSOMAL MAPPING OF THE HUMAN MOUSE, AND RAT HOMOLOGUES", IMMUNOGENETICS,DE,SPRINGER VERLAG, BERLIN, vol. 49, no. 5, May 1999 (1999-05-01), pages 369 - 375, XP000881731, ISSN: 0093-7711
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 November 1999 (1999-11-01), HINXTON, GB, XP002144040
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 22 May 1997 (1997-05-22), HINXTON, GB, XP002144033
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 18 April 1997 (1997-04-18), HINXTON, GB, XP002144034
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 30 March 1998 (1998-03-30), HINXTON, GB, XP002144054
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 15 January 1997 (1997-01-15), HINXTON, GB, XP002144055
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 February 1997 (1997-02-01), HINXTON, GB, XP002144035
KURAMOCHI ET AL: "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 36, 5 September 1997 (1997-09-05), pages 22679 - 22684-22684, XP002132505, ISSN: 0021-9258
CREASY C L ET AL: "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 167, no. 1, 1995, pages 303 - 306, XP004043060, ISSN: 0378-1119
SCHAAR D G ET AL: "THE IDENTIFICATION OF A NOVEL CDNA PREFERENTIALLY EXPRESSED IN THE OLFACTORY-LIMBIC SYSTEM OF THE ADULT RAT", BRAIN RESEARCH,NL,AMSTERDAM, vol. 721, 30 January 1996 (1996-01-30), pages 217 - 228, XP000881673, ISSN: 0006-8993
GRAVES JONATHAN D ET AL: "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 8, 15 April 1998 (1998-04-15), pages 2224 - 2234, XP002144036, ISSN: 0261-4189
SCHINKMANN ET AL: "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 45, 7 November 1997 (1997-11-07), pages 28695 - 28703, XP002086764, ISSN: 0021-9258
SUSUMU ITOH ET AL: "Molecular cloning and characterization of a novel putative STE20-like kinase in Guinea pigs", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,US,NEW YORK, US, vol. 340, no. 2, 15 April 1997 (1997-04-15), pages 201 - 207, XP002079735, ISSN: 0003-9861
ICHIJO HIDENORI ET AL: "Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.", SCIENCE (WASHINGTON D C), vol. 275, no. 5296, 1997, pages 90 - 94, XP000933551, ISSN: 0036-8075
FANGER G R ET AL: "MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?", CURRENT OPINION IN GENETICS & DEVELOPMENT,XX,CURRENT BIOLOGY LTD, vol. 7, February 1997 (1997-02-01), pages 67 - 74, XP000867511, ISSN: 0959-437X
NOBES CATHERINE D ET AL: "Rho, Rac, and Cdc42 GTPases Regulate the Assembly of Multimolecular Focal Complexes Associated with Actin Stress Fibers, Lamellipodia, and Filopodia.", CELL, vol. 81, no. 1, 1995, pages 53 - 62, XP000929500, ISSN: 0092-8674
MANSER EDWARD ET AL: "Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 3, 1997, pages 1129 - 1143, XP002144038, ISSN: 0270-7306
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 July 1997 (1997-07-01), HINXTON, GB, XP002144039
KURAMOCHI S ET AL: "MOLECULAR CLONING OF THE HUMAN GENE STK10 ENCODING LYMPHOCYTE- ORIENTED KINASE, AND COMPARITIVE CHROMOSOMAL MAPPING OF THE HUMAN MOUSE, AND RAT HOMOLOGUES", IMMUNOGENETICS,DE,SPRINGER VERLAG, BERLIN, vol. 49, no. 5, May 1999 (1999-05-01), pages 369 - 375, XP000881731, ISSN: 0093-7711
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 November 1999 (1999-11-01), HINXTON, GB, XP002144040
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