Title:
CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/193951
Kind Code:
A1
Abstract:
Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.
Inventors:
HE HAIYING (CN)
WU SONGLIANG (CN)
LUO ZHI (CN)
MOU JIANFENG (CN)
GUO FENGYING (CN)
WANG CHUAN (CN)
LI GUOQING (CN)
ZENG MINGGAO (CN)
CHEN SHUHUI (CN)
WU SONGLIANG (CN)
LUO ZHI (CN)
MOU JIANFENG (CN)
GUO FENGYING (CN)
WANG CHUAN (CN)
LI GUOQING (CN)
ZENG MINGGAO (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2017/083909
Publication Date:
November 16, 2017
Filing Date:
May 11, 2017
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D211/62; A61K31/445; A61K31/46; A61P35/00; A61P43/00; C07C237/12; C07D205/04; C07D211/60; C07D401/06; C07D409/06; C07D451/02
Domestic Patent References:
| WO2012021800A2 | 2012-02-16 | |||
| WO2015175381A1 | 2015-11-19 | |||
| WO2000023421A1 | 2000-04-27 | |||
| WO2001090070A2 | 2001-11-29 |
Foreign References:
| US20030096737A1 | 2003-05-22 |
Other References:
UENO, H. ET AL.: "Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 1, 1 January 2009 (2009-01-01), pages 199 - 202, XP025816906
See also references of EP 3456711A4
See also references of EP 3456711A4
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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