Title:
CATALASE NANOCAPSULES AND METHODS FOR USE
Document Type and Number:
WIPO Patent Application WO/2021/168996
Kind Code:
A1
Abstract:
It relates to a nanocapsule comprising an enzyme capable of neutralizing excessive production of reactive oxygen species in a subject with the enzyme being encapsulated in a polymer. It also relates to a scale up synthesis of the nanocapsule. It further relates to a method of treating a disease or disorder e. g. a viral pneumonia (for example COVID-19 pneumonia), an immune disorder, cytokine release syndrome, or oxidative stress, comprising administering said nanocapsule to a person in need thereof.
Inventors:
GAN ZHIHUA (CN)
PANG SHEN (US)
WANG FANG (CN)
QIN MENG (CN)
YU QINGSONG (CN)
NING ZHENBO (CN)
HOU YI (CN)
NIE KAILI (CN)
JIANG NI (CN)
LIU CHAOYONG (CN)
PANG SHEN (US)
WANG FANG (CN)
QIN MENG (CN)
YU QINGSONG (CN)
NING ZHENBO (CN)
HOU YI (CN)
NIE KAILI (CN)
JIANG NI (CN)
LIU CHAOYONG (CN)
Application Number:
PCT/CN2020/083506
Publication Date:
September 02, 2021
Filing Date:
April 07, 2020
Export Citation:
Assignee:
VIVIBABA INC (US)
GAN ZHIHUA (CN)
GAN ZHIHUA (CN)
International Classes:
A61K9/51; A61K9/00; A61K9/50; A61K38/44; A61P11/00; A61P31/12; A61P31/14; A61P37/00; B01J13/18
Domestic Patent References:
| WO2013123492A2 | 2013-08-22 |
Foreign References:
| CN104549085A | 2015-04-29 | |||
| CN106669822A | 2017-05-17 | |||
| CN109266639A | 2019-01-25 | |||
| US20190365869A1 | 2019-12-05 |
Other References:
QI HONGZHAO, YANG LIJUN, SHAN PEIPEI, ZHU SUJIE, DING HAN, XUE SHENG, WANG YIN, YUAN XUBO, LI PEIFENG: "The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels", PHARMACEUTICS, vol. 12, no. 2, 1 February 2020 (2020-02-01), XP055841039, DOI: 10.3390/pharmaceutics12020115
KHOMICH OLGA, KOCHETKOV SERGEY, BARTOSCH BIRKE, IVANOV ALEXANDER: "Redox Biology of Respiratory Viral Infections", VIRUSES, vol. 10, no. 8, 26 July 2018 (2018-07-26), XP055841040, DOI: 10.3390/v10080392
LIANG SHENG; LIU YANG; JIN XIN; LIU GAN; WEN JING; ZHANG LINLIN; LI JIE; YUAN XUBO; CHEN IRVIN S.; CHEN WEI; WANG HUI; SHI LINQI; : "Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins", NANO RESEARCH, TSINGHUA UNIVERSITY PRESS, CN, vol. 9, no. 4, 1 February 2016 (2016-02-01), CN, pages 1022 - 1031, XP035675036, ISSN: 1998-0124, DOI: 10.1007/s12274-016-0991-3
KHOMICH OLGA, KOCHETKOV SERGEY, BARTOSCH BIRKE, IVANOV ALEXANDER: "Redox Biology of Respiratory Viral Infections", VIRUSES, vol. 10, no. 8, 26 July 2018 (2018-07-26), XP055841040, DOI: 10.3390/v10080392
LIANG SHENG; LIU YANG; JIN XIN; LIU GAN; WEN JING; ZHANG LINLIN; LI JIE; YUAN XUBO; CHEN IRVIN S.; CHEN WEI; WANG HUI; SHI LINQI; : "Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins", NANO RESEARCH, TSINGHUA UNIVERSITY PRESS, CN, vol. 9, no. 4, 1 February 2016 (2016-02-01), CN, pages 1022 - 1031, XP035675036, ISSN: 1998-0124, DOI: 10.1007/s12274-016-0991-3
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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