CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. application Serial No. 07/324,718 filed March 17, 1989, which was a continuation-in-part of U.S. application Serial No. 07/210,555 filed June 23, 1988. FIELD OF INVENTION

Process for the preparation of highly fluorinated alkanes by contacting halogenated alkenes or alkanes with hydrogen fluoride (HF) in the presence of TaFs or NbFs and excess HF. BACKGROUND OF INVENTION

A. E. Feiring, Journal of Fluorine Chemistry, 13, 7-18 (1979) discloses the use of tantalum pentafluoride as a catalyst for the addition of hydrogen fluoride to tetra- and trichloroethene and related compounds. The catalyst is also useful in fluorine-chlorine exchange reactions.

The use of tantalum pentafluoride as a catalyst for the addition of hydrogen fluoride to unsaturated compounds has been disclosed and claimed in Feiring, U.S. 4,258,225.

The need to provide economically attractive processes to convert certain halocarbon starting materials to highly fluorinated, hydrogen-containing alkanes useful as alternatives to current products for refrigerants, blowing agents, etc. has sparked interest in this area. The use of TaFs ^or NbFs under the conditions taught by Feiring, specifically as set forth in Column 1, Lines 62 to 63 of U.S. 4,258,225, requires "1 to 8 molar equivalents of HF and in the presence of 0.01 to 0.25 molar equivalents of TaFs or

NbFs to produce a fluorinated alkane." These conditions are advantageous for addition of HF to the olefinic bonds of the starting halogenated alkenes, but are far less favorable to halogen exchange on the resulting adducts. Consequently, while highly fluorinated alkanes can be produced, the yields are too small for economically attractive production. In accordance with this invention it has been discovered that utilizing a combination of high specific catalyst loading plus a high ratio of catalyst and HF to halocarbon starting material enables the direct preparation of many highly fluorinated alkanes in economically attractive yields.

It is a particular object of this invention to provide a liquid-phase process for the preparation of 2,2-dichloro-l,l,l-trifluoroethane (HCFC-123) in high yields and with a low content of other isomers. Another object is to provide such a high yield, high purity CF ₃ CHCI2 process which enables the use of relatively low HF concentrations, thereby minimizing HF-induced reactor corrosion and the need for high cost, high pressure equipment.

HCFC-123 is an environmentally-acceptable alternate to trichlorofluoromethane (CFC-11) as a blowing agent, solvent, tobacco puffing agent and refrigerant. HCFC-123 is also a useful raw material for preparing 2-chlσro-l,1,1,2-tetrafluoroethane (HCFC-124) and pentafluoroethane (HFC-125) which are environmentally-acceptable products. HCFC-124 is useful as a blowing agent, sterilant carrier gas, propellant, refrigerant and raw material for preparing 1,1,1,2-tetrafluoroethane (HFC-134a) - a zero-ozone- depletion-potential replacement for dichlorαdifluoro- methane (CFC-12) as a refrigerant. HFC-125 is a zero-ozone-depletion-potential replacement for R-502

[an azeotropic blend of chlorodifluoromethane (HCFC-22) and chloropentafluoroethane (CFC-115) ] . HFC-125 is also a useful raw material for preparing tetrafluoroethylene (TFE) and a long-term candidate replacement for HCFC-22.

SUMMARY OF THE INVENTION This invention provides a process for preparing fluorinated alkanes of the formula

R ¹ R ² R ³ C-CR ⁴ R ⁵ R ⁶

wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are individually selected from H, F and Cl, wherein at least one of R , R ² and R ³ is H, and at least one of R ⁴ , R ⁵ and R ⁶ is F by contacting, at a temperature from 0°C to 175°C under substantially anhydrous conditions, one molar equivalent of a halogenated alkene of the formula

R ¹ R ² C=CR ³ R ⁴

wherein R ¹ , R ² , R ³ and R ⁴ are individually selected from H, F and Cl, with at least the stoichiometric molar equivalent of HF in the presence of at least 0.25 molar equivalent of at least one catalyst selected from tantalum pentafluoride (TaFs) ^anc niobium pentafluoride (NbFs) _> with the proviso that the number of moles, x, of catalyst plus the number of moles, y, of HF, relative to the number of moles, z, of the halogenated starting material, are such that the total fluorine-to-starting material ratio,

(5x+y)/z, equals at least (6-w) , preferably (10-w) where w is the number of fluorine atoms in one mole of starting material.

This invention also provides for the preparation of the fluorinated alkanes described

above, under substantially the same process conditions, utilizing a chlorinated alkane of the formula

HR1R2 _C -CR R ⁴ C1

wherein R ¹ and R ² are individually selected from H and Cl, and wherein R ³ and R ⁴ are individually selected from H, Cl and F.

Utilizing substantially the same process conditions, this invention also provides for the preparation of fluorinated alkanes of the formula

R ¹ R ² R ³ C-CR R5-CR ⁶ R ⁷ R ⁸

wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ are individually selected from H, F and Cl, wherein at least one of R ⁴ and R ⁵ is H, and at least one of R ⁶ , R ⁷ and R ⁸ is F, from an alkene of the formula

R ^l R ² R ³ C-CR ⁴ =CR ⁵ R ⁶

wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are individually selected from H, F and Cl. It is preferred that R ¹ , R ² and R ³ are individually selected from F and Cl, and that R ⁴ , R ⁵ and R ⁶ be Cl. The fluorinated alkanes described above can also be prepared utilizing substantially the same process conditions from a chlorinated alkane of the formula

R ¹ R ² R ³ C-CR ⁴ R5-CR ⁶ R ⁷ R ⁸

wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ are individually selected from H, F and Cl, with the proviso that at least one of R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ ,

R ⁷ and R ⁸ is Cl. It is preferred that R ³ , R ⁷ and R ⁸ are Cl, R ⁴ and R ⁵ are F, and R ⁶ is H.

All the fluorinated alkanes produced in accordance with this invention are characterized by having at least one more, and preferably more than one more, fluorine atom than the halogenated alkene or alkane utilized as the starting material, and at least one of the fluorine atoms present in the fluorinated alkane so produced is the result of a halogen exchange reaction.

DETAILS OF THE INVENTION In a typical embodiment of the invention which provides for fluorinated alkanes from halogenated alkenes having two carbons, the reaction proceeds as follows:

C1 ₂ C=CC1 ₂ + HF > CC1 ₂ F-CHC1 ₂

Addition of HF

CC1 ₂ F-CHC1 ₂ + HF > CClF ₂ -CHCl2 + HC1

Halogen Exchange CC1F ₂ -CHC1 ₂ + HF > CF3-CHCI2 + HC1

Halogen Exchange

CF3-CHCI2 + HF > CF3-CHCIF + HC1

Halogen Exchange Starting with the corresponding two carbon alkane the reaction proceeds as follows:

HC1 ₂ C-CHC1 ₂ + HF > HC1FC-CHC1 ₂ + HC1

Halogen Exchange

HCIFC-CHCI2 + HF > HF ₂ C-CHC1 ₂ + HC1

Halogen Exchange HF2C-CHCI2 + HF > F3C-CH2CI + HC1

Halogen Exchange and Rearrangement The degree to which the halogen exchange reactions proceed can be varied in accordance with this invention, particularly by varying the amount of HF and catalyst in combination as described herein below. To achieve the optimum degree of halogen

exchange at least 0.25 molar equivalent of TaFs or NbFs, or mixtures thereof and, preferably from 0.25 to 5.0 molar equivalents, based on the starting material, are required. The range of preference for effectiveness and economy is from 0.27 to 4.0 molar equivalents. The catalyst, preferably tantalum pentafluoride, is a commercially available crystalline solid and can be used alone or on a support such as carbon or fluorinated alumina. In combination with the catalyst it is also necessary to utilize at least a specified minimum molar equivalent of HF, based on the halocarbon starting material, to achieve optimum halogen exchange and consequent high yields of highly fluorinated alkanes.

At relatively low catalyst concentrations, e.g., from 0.25 to about 0.5 mole per mole of starting material, the amount of HF will normally be greater than 8 moles per mole of starting material and can be as high as about 30 moles, preferably 15 to 30 moles per mole of the starting material. Fewer molar equivalents of HF, approaching the stoichiometrically required proportions, can be employed in conjunction with molar equivalents of catalyst greater than 0.5 mole per mole of starting material.

Thus, with tantalum pentafluoride at a concentration of 1 to 5 moles ^* per mole of starting material, the amount of HF can be as low as the stoichiometric amount, provided that the concentrations of catalyst, HF and starting material are such as to constitute a high total fluorine to starting material ratio, as defined above. That is to say, when (5x+y) is divided by "z", the quotient will equal at least (6-w) , preferably at least (10-w) , where "x" is the number of moles of tantalum penta¬ fluoride, "γ' ^r is the number of moles of HF employed

and "z" is the number of moles of the starting material to be fluorinated, and "w" is the number of fluorine atoms in the starting material.

Preferably, the relative proportions of the reactant materials will be such that the indicated ratio (5x+y)/z is in the range of 15/1 to 35/1. Higher ratios provide little or no additional benefits. For example, in the manufacture of HCFC-123 from CCl2=CCl2 (wherein w=0 since there is no fluorine in the starting material) attractive results can be obtained with about 3 to 4 molar equivalents of TaFs, the catalyst, in combination with as little as 3 to 4 molar equivalents of HF per mole of CCl2=CCl2, thereby greatly minimizing the problems of manufacture associated with the use of higher molar proportions of HF.

It should be noted that Ta and Nb pentachlorides are readily converted to the pentafluorides by reaction with HF under ambient conditions. Thus, the metal pentafluoride can be prepared for use in the process of the invention just prior to initiating the HF-starting material reaction for the preparation of the desired polyfluorinated organic product. Under the preferred conditions of the invention, when the starting halogenated alkene or alkane is Cl2C=CCl2, CI3CCHCI2, CC1 ₂ FCHC1 ₂ or CCIF2CHCI2, the favored product will be CF ₃ CHCI ₂ , and when the starting halogenated alkene or alkane is C1 ₂ C=CHC1, FC1C=CHC1, HCl ₂ CCHCl2, HC1FCCHC1 ₂ ,

HF ₂ CCHC1 ₂ , C1 ₃ CCH ₂ C1, FCI2CCH2CI or F2CICCH2CI, the favored product is CF3CH2CI. When the starting halogenated alkene or alkane is Cl ₂ C=CH ₂ , FC1C=CH ₂ or CI ₃ C-CH ₃ , the product can be CFCI2CH ₃ , CF2CICH ₃ and/or CF3CH ₃ , depending on process conditions.

A variety of halogenated alkenes and halogenated alkanes, or mixtures thereof, may be utilized as starting materials in the practice of this invention. Preferred alkenes of the formula R ¹ R ² C=CR ³ R ⁴ are wherein R ¹ is H or Cl while R ² , R ³ and R ⁴ are Cl, or wherein R ¹ and R ² are H and R ³ and R ⁴ are Cl. The preferred halogenated alkanes of the formula HR ¹ R ² C-CR ³ R C1 are wherein R ¹ , R ² , R ³ and R ⁴ are Cl, wherein R ¹ is H and R ² , R ³ and R ⁴ are Cl, or wherein R ¹ and R ² are H and R ³ and R ⁴ are Cl.

The specifically preferred halogenated alkenes and alkanes are CCl2=CCl2, CHC1=CC1 ₂ , CH ₂ =CC1 ₂ , CCI ₃ CHCI2, CHCI2CHCI2, CCI3CH2CI and CCI ₃ CH ₃ . In the production of CF ₃ CHCI2 (HCFC-123) from any of the above precursors, it has been found that isomers of HCFC-123 are also formed in relatively high and objectionable amounts. The isomers consist mainly of CCIF2CHCIF (HCFC-123a) and lesser amounts of CC1 ₂ FCHF ₂ (HCFC-123b) . It has also been found that the isomer content of the reaction product can be substantially reduced (to as low as non-detectable levels) when the products remain in contact with the reaction mass for a time sufficient to accomplish the desired low isomer result. By sufficient time is meant to include reaction time under autogenous pressure conditions and residence time under continu¬ ous process conditions wherein HF and the raw material are fed together to a liquid reaction mass containing metal pentafluoride and fluorination products of reaction, and the reaction product stream is continu¬ ously removed therefrom, with the reaction pressure maintained by controlling the amount of escaping gases. In such a process, residence time is deter- mined by, and controlled by, the HF and starting

material feed rates, the reaction temperature and pressure and the temperature of the gas leaving the reactor.

Anhydrous or substantially anhydrous conditions means that water, which is detrimental to the reaction, should be excluded as much as possible from the reaction zone. The HF which is commercially available can be used in the reaction directly. The halogenated alkenes and alkanes, and the catalysts also contain little or no water and can similarly be used directly. Exclusion of moisture from the reaction vessel by means of appropriate moisture traps, etc., is a routine procedure and is well known in the art. The reaction can be carried out batchwise or in a continuous manner in the liquid phase at from 0°C to 175°C, and preferably from 60°C to 160°C. At reaction temperatures below these limits the reactions become too slow to be useful, and at temperatures above these limits the yields of products are lowered by side reactions and polymerization.

The reaction vessel is constructed from materials which are resistant to the action of hydrogen fluoride. Examples include stainless steels, high nickel alloys such as monel, ^/ Hastelloy and "Inconel", and plastics such as polyethylene, polypropylene, polychlorotrifluoroethylene and polytetrafluoroethylene. The high nickel alloys are preferred because of the superacidities of TaFs ^an & NbFs in combination with liquid HF. For reactions at a temperature either below the boiling point of hydrogen fluoride (19.5°C) or below the boiling point or the most volatile reactant, the reaction vessel can be closed or open to the atmosphere if provisions to exclude moisture are taken. For reactions at a temperature at or above the boiling point of hydrogen

fluoride or the most volatile component, a closed vessel or a pressure-regulated partially open reactor is used to minimize the loss of reactants.

Pressure is not critical. Atmospheric and autogenous pressures are the most convenient and are therefore preferred. Means can be provided for the venting of the excess pressure of hydrogen chloride formed in the substitution reaction and can offer an advantage in minimizing the formation of side products.

In general, the reactions are conducted by introducing the reagents in any order into the reaction vessel. Generally, in batch-type autogenous pressure operation, the catalyst and starting material are placed in the reaction vessel which is then cooled, and the required amount of hydrogen fluoride is condensed in the vessel. The vessel may be cooled in Dry Ice or liquid nitrogen and evacuated prior to the introduction of hydrogen fluoride to facilitate the hydrogen fluoride addition. The contents of the vessel are raised to the appropriate reaction temperature and agitated by shaking or stirring for a length of time sufficient to cause the reaction to occur. The reaction times can be from 1 to 17 hours; the preferred reaction times are from 1 to 6 hours.

As indicated above, the fluorination reaction can be conducted in a continuous or semi-continuous manner with HF and the halocarbon starting material fed continuously or intermittently to a reaction vessel containing the Ta or Nb pentahalide at a temperature and pressure effective to result in the fluorination of the starting material to the desired polyfluorinated product. Preferably, the temperature and pressure are such that the desired product(s) is(are) in the gaseous state, so that a reaction product stream can be removed continuously or

intermittently from the reaction zone. The pressure within the reactor can be controlled by means of a pressure regulator, and the temperature of the reac¬ tion product stream can be controlled, if desired, by use of a condenser/dephlegmator, all these techniques being well-known to the art.

It is convenient to initiate the HF-starting material reaction with the metal pentahalide in the presence of a diluent which may be a high-boiling inert liquid, e.g., a perfluorinated ether, or the desired reaction product itself, for example, HCFC-123 in the process for the manufacture of HCFC-123. When the available metal pentahalide is the pentachloride it is conveniently converted to the pentafluoride by treatment with HF and the removal of the hydrogen chloride by-product before initiating the reaction of HF with the halogenated starting material in the presence of the metal, preferably tantalum, pentafluoride. The products are isolated by any of a variety of well-known techniques such as distillation or drowning into ice, washing with aqueous caustic, then water and drying with molecular sieves. A special isolation procedure involves scrubbing in 20.7% aqueous HC1 precooled to -60 °C. This permits collection of products boiling below ice temperature. The scrubbed products can be further purified by fractional distillation.

The highly fluorinated alkanes produced by the instant invention are useful as refrigerants, solvents and blowing agents. Those containing hydrogen are particularly useful in that they have reduced impact on the environment. They can also be

used as starting materials for the preparation of other useful compounds.

EXAMPLES In the following illustrative Examples all parts are molar proportions, and all temperatures are Centigrade. All reactions used commercial anhydrous HF and were carried out with the exclusion of water. The product mixtures were analyzed by Gas Chromatography (GC) and mass spectroscopy to identify the individual products. Analyses, where given, are in area percent unless otherwise indicated.

EXAMPLE 1 In a platinum-lined bomb were heated 0.036 mole of TaFs, 0.097 mole of tetrachloroethylene and 2.0 moles of HF at 150°C for 3 hours. The mole ratio of HF/tetrachloroethylene was 20.6 and of TaFs/tetrachloroethylene was 0.37. While liquid organic products were not isolated in the scrubbing system, the off-gases contained 95.2% of CF3CHC1 ₂ , 1.4% of CF2CICHCI2 and 0.9% of CF ₃ CHFCI.

EXAMPLE 2 The procedure of Example 1 was followed except that 0.100 mole of CF2CICHCI2 was used instead of tetrachloroethylene. The mole ratio of HF/CF2CICHCI2 was 20 and of aFs/CF2ClCHCl2 was 0.36. The off-gases contained 95.6% of CF ₃ CHCI2, 1.7% of CF ₂ C1CHC1 ₂ and 0.9% of CF ₃ CHFCI.

EXAMPLE 3 In a stainless steel pressure vessel closed with a valve were stirred 0.072 mole of TaFs, 0-175 mole of tetrachloroethylene and 3.93 moles of anhydrous HF while heating at about 108°C for 2 hours. The mole ratio of HF/tetrachloroethylene was 22.5 and of TaF5/tetrachloroethylene was 0.41. The cylinder was cooled to -70°C, and the HC1 present was vented.

The remaining volatiles were collected by vacuum-line transfer into a gas cylinder cooled to -70"C while heating the pressure vessel. These volatiles were scrubbed in 20.7% aqueous HC1 precooled to -60°C and maintained near the temperature. The 17.0 g of colorless oil collected after scrubbing and water-washing contained 20.4% of CF3CHC1 ₂ , 0.6% of CF ₂ C1CHC1F, 77.9% of CF ₂ C1CHC1 ₂ , 0.5% of CFC1 ₂ CHC1 ₂ , and 0.2% of a mixture of CF ₃ CHFCI and CF ₂ C1CHF ₂ . EXAMPLE 4

The procedure of Example 3 was followed using 0.071 mole of TaFs, 0.184 mole of tetrachloroethylene and 3.78 moles of anhydrous HF and reacting at about 130°C for 2 hours. The mole ratio of HF/tetrachloroethylene was 20.5 and of

TaFs/tetrachloroethylene was 0.39. The 14.0 g of isolated organic liquid contained 64.7% of CF ₃ CHC1 ₂ , 34.0% of CF C1CHC12, 0.3% of CFCl ₂ CHCl2 and 0.3% of a mixture of CF ₃ CHFCI and CF ₂ C1CHF2. EXAMPLE 5

The procedure of Example 3 was followed using 0.063 mole of TaFs, 0.172 mole of pentachloroethane and 3.72 moles of anhydrous HF and reacting at about 110°C for 2 hours. The mole ratio of HF/pentachloroethane was 21.6 and of

TaFs/pentachloroethane was 0.36. The 17.0 g of isolated organic liquid contained 15.4% of CF3CHCI2, 0.8% of CF ₂ C1CHFC1, 82.5% of CF ₂ C1CHC1 ₂ , 0.5% of CFCI2CHCI2 and 0.5% of a mixture of CF3CHFCI and CF2CICHF2.

EXAMPLE 6 The procedure of Example 3 was followed using 0.072 mole of TaFs, 0.194 mole of tetrachloroethylene and 3.91 moles of anhydrous HF while heating at about 150°C for 2 hours. The mole

ratio of HF/tetrachloroethylene was 20.2 and of TaFs/tetrachloroethylene was 0.37. The 10.0 g of isolated organic liquid consisted of 97.2% of CF3CHCI2, 1.2% of CF ₂ C1CHC1 ₂ and 1.0% of a mixture of CF ₃ CHFCI and CF ₂ C1CHF ₂ .

EXAMPLE 7 The procedure of Example 6 was followed but with a different isolation technique. The mole ratio of HF/tetrachloroethylene was 19.8 and of TaFs/tetrachloroethylene was 0.36. After the 2-hour reaction period at about 150 ^β C, the volatiles in the pressure vessel were vented hot directly into 20.7% aqueous HCl at -50 " C. The colorless liquid organic product collected, containing 97.0% of CF ₃ CHC1 ₂ , was shown by infrared spectroscopy to contain a maximum of 1% of CF ₂ C1CHFC1.

EXAMPLE 8 The procedure of Example 3 was followed using 0.076 mole of TaFs, 0.283 mole of as-tetrachloroethane (CCl ₃ CH Cl) and 3.96 moles of HF and reacting at about 85°C for 2 1/2 hours. The mole ratio of HF/CCl ₃ CH ₂ Cl was 14.0 and of TaFs/CCl3CH Cl was 0.27. The isolated organic products, which were gaseous above 15"C, consisted of 95.4% of CF ₃ CH ₂ C1, 0.9% of CF =CC1 ₂ and 0.7% of CC1 ₂ =CHC1.

EXAMPLE 9 The procedure of Example 3 was followed using 0.079 mole of TaFs, 0.296 mole of trichloro- ethylene and 4.12 moles of HF and reacting at about 102 ^β C for 2 hours. The mole ratio of HF/trichloro- ethylene was 13.9 and of TaFs/trichloroethylene was 0.27.. The isolated volatile organic products, which were gaseous above 15°C, consisted of 95.2% of CF ₃ CH ₂ C1, 0.1% of CF ₃ CH ₃ , 3.9% of C4H ₃ CIF6

isomers, and 0.1% of C ₃ HCIF ₆ isomers, and 0.4% of C5H4F6 isomers.

EXAMPLE 10 Into a 150 ml. capacity stainless steel pressure cylinder was placed 0.093 mole of TaFs. ^Tne cylinder was then closed with a valve, after which 0.366 mole of tetrachloroethylene and 3.698 moles of HF were added to the cylinder at about -70 ^β C and under vacuum. The cylinder was warmed to room temperature and then placed in a preheated oil bath. The contents of the cylinder were stirred magnetically and heated to the reaction temperature of over 15-20 minutes. The reaction proceeded at the reaction temperature, 143°C to 150°C, for 2 hours, after which time the cylinder was cooled to about -70°C. Any contents of the cylinder which were not condensible at -70 ^β C (primarily HCl) were vented. The volatiles (organics plus unreacted HF) were then vacuum-line distilled out into a receiver cylinder at about -70°C while heating the reaction cylinder to about 100°C. The volatiles were scrubbed in 20.7% aqueous HCl at about -50°C. The separated organic liquid was collected and dried over 4A molecular sieves. The organic liquid was analyzed by gas chromatography and mass spectroscopy, and the results are shown in Table 1. The residue in the stainless steel reaction cylinder was found to contain only recovered Ta compounds and corrosion products.

COMPARATIVE EXAMPLE 10A The procedure of Example 10 was followed except that 0.034 mole of TaFs, 0.383 mole of tetrachloroethylene, and 3.838 moles of HF were used. The results, shown in Table 1, reveal that the presence of high HF alone does not result in high yield of the desired highly fluorinated alkane, in

this case 2,2-dichloro-l,1,1-trifluoroethane (CF ₃ CHC1 ₂ ).

TABLE 1

Comp

Ex. 10 Ex. A

HF/PCEl Mole Ratio 10.10/1 10.02/1 TaFs/PCE ^' Mole Ratio 0.25/1 0.09/1 Volatiles (grams) 134.82 138.79 Reactor Residue (grams) 21.5 9.81 Recovery (%) 97.5 99.2

Organic Liquid (grams) 48.1 51.84

Analysis of Organic Liquid (area %)

CF3CHC12 95.01 47.84

CF ₂ C1CHC1 ₂ 3.85 50.35

CF ₂ C1CHF ₂ 0.17 0.07

CF3CHFCI 0.17 0.03

CF3CH ₂ C1 0.58 0.67

CFC1 ₂ CHF ₂ 0.01 0.05

CF ₂ C1CHFC1 ND ² 0.46

CFC1 CF ₂ C1 0.02 0.02

CC1 ₃ CHF ₂ ND 0.06

CFC1 ₂ CHC1 ₂ 0.04 0.24

1 Tetrachloroethylene ² Not Detected.

EXAMPLE 11 In a dry 150 ml stainless steel cylinder equipped with a valved closure and containing a "Teflon" polytetrafluorethylene-coated magnetic stirring bar was loaded, in a dry box under dry 2, 225 g (0.815 mole) of TaFs (99% purity). The cylinder was closed, pressure-tested to 500 psig with N2, cooled in Dry Ice-methanol and evacuated. To the cylinder were then added 39.7 g (0.239 mole) of

tetrachloroethylene and 15.7 g (0.785 mole) of anhydrous HF. The cylinder was then closed, allowed to warm to room temperature and place in an oil bath preheated to 155"C. Magnetic stirring was started, and the reaction mixture was allowed to temperature-equilibrate for 30 minutes. With the oil bath at 149-150°C, vapor samples were withdrawn from the reactor over a 120 minute period into 20.7% aqueous HCl precooled to about -50°C. The organic liquids of these samples were drawn off, dried with molecular sieves and analyzed gas chromatographically to determine their composition. The analyses showed that, during the warm-up period, 85% of the tetrachloroethylene was converted to a mixture 5% by weight CCl ₂ FCHCl2

(HCFC-121), 40% CC1F ₂ CHC1 ₂ (HCFC-122) and 40% CF ₃ CHCl ₂ (HCFC-123) containing 0.45% CC1F CHC1F (HCFC-123a) .

After 90 minutes at 149-150°, the CC1 =CC1 ₂ conversion was 96%, and the organic reaction products consisted of 2% CC1 ₂ FCHC1 ₂ , 18% CC1F CHC1 ₂ and 76% CF ₃ CHC1 ₂ with its isomer, CC1F ₂ CHC1F, no longer detectable by gas chromatography. Little additional reaction occurred on continued heating of the reaction mixture. Apparently, the available HF had been consumed in the fluorination process and in the venting of the cylinder for sampling.

It will be noted that, in the above run, the TaF5/C ₂ Cl4 mole ratio is 3.41, the HF/C Cl4 mole ratio is only 3.29 (about 10% excess over stoichiometric) and the total fluorine-to-C ₂ Cl4 ratio is

[5x0.815+0.785]/0.239 or 20.3. It is also noteworthy that, under these high fluorine-to-C ₂ Cl4 conditions, CF ₃ CHCI2 is obtained in good yield and substantially isomer-free.

EXAMPLE 12 A 13.5 gallon reactor, equipped with an agitator, a means for feeding HF and CC1 ₂ =CC1 ₂ , a condenser and a pressure-relief valve, was charged with 20.4 lbs. (0.057 lb-mole) of TaCls and 40 lbs of 99.999% CF3CHCI2 as diluent during the initial stages of the reaction. The TaCls was converted to TaFs by- the addition of an excess of anhydrous HF at about 25°C with stirring until HCl was no longer evolved. The resulting TaFs/CF3CHCl mixture was then heated with stirring to 125" and maintained at 125-132° while simultaneously feeding HF at 2-4.5 Ibs/hr. and CC1 ₂ =CC1 ₂ at 3-8.5 lbs/hr. over a total reaction period of 150 hours. During this time the reactor pressure was varied from 360 to 465 psig and the condenser temperature from 80° to 100°. The above variations in the process conditions were employed to determine the effect of residence time on the yield and quality of the desired CF3CHCI2 product. The residence time of the reaction products in the reactor was varied during the run between 1.2 and 30.6 hours by varying the HF and C2CI4 feed rates, the reaction temperature and pressure and the off-gas (condenser) temperature. During the run, the vapor products exiting the reactor was sampled and analyzed gas-chromatographically for their contents of CF3CHC1 ₂ (HCFC-123), CC1F ₂ CHC1F (HCFC-123a) and CCl ₂ FCHF ₂ (HCFC-123b) , the isomer content being a measure of the quality of the HCFC-123 being produced. Table 2 presents the analytical results as a function of residence time in the order in which they were obtained.

TABLE 2

Residence %HCFC- 123a %HCFC-123b

Time. Hrs. %HCFC-123 In Vap or In Vapor

3.0 82.3 2.7 0.41 1.2 34.8 13.4 0.41

18.7 97.8 0.07 nil

16.9 97.8 0.16 nil

14.5 98.4 0.07 nil

30.6 99.1 _% 0.02 nil The results show that, under the conditions of the continuous feed process, the longer the residence time, the lower the content of the unwanted isomers in the CF3CHCI2 product.

It will be appreciated that, in the above continuous feed process, both the HF/C Cl4 mole ratio and the TaFs/C Cl4 mole ratio, although varied considerably during the run, were sufficiently high throughout the run to provide high total fluorine to C ₂ Cl4 ratios well in excess of the required 10, with the result that CF ₃ CHC1 ₂ was produced in high yields. Furthermore, through control of residence time, the CF ₃ CHC1 ₂ could be obtained substantially free of its isomers.

EXAMPLE 13 The procedure of Example 12 was repeated, except that the quantity of TaCls was more than doubled and corresponded to 0.135 lb-mole. Again, it was determined that the isomer production decreased with increasing residence time, and it was further found that increasing the TaFs loading shortened the residence time needed to produce CF ₃ CHCI2 substantially free of its isomers.