Title:
CATION EXCHANGE CHROMATOGRAPHY CARRIER FOR REFINING OF ANTIBODIES, AND METHOD FOR SEPARATION OF ANTIBODY MONOMERS FROM POLYMERS THEREOF PRODUCED IN ANTIBODY DRUG MANUFACTURING PROCESS
Document Type and Number:
WIPO Patent Application WO/2014/061411
Kind Code:
A1
Abstract:
Provided is a cation exchange chromatography carrier that can be used suitably for refining of antibodies, and particularly a cation exchange chromatography carrier having satisfactory ability to separate antibody monomers from polymers thereof which are produced in an antibody drug manufacturing process. The cation exchange chromatography carrier for use in refining of antibodies comprises a base carrier containing porous particles, to which is bound a polymer containing at least one strongly cationic monomer unit represented by formula (1) or formula (2) below, in a range of 30 to 100 mol%, inclusive, of the total monomer, the ion exchange capacity of the cation exchange chromatography carrier being from 60 to 300 μmol/ml inclusive. [Formula 1] (In the formula, R1, R2, and R3 are independently a hydrogen atom or methyl; and A1 and A2 are -R4-SO3M, where R4 is C2-C4 alkylene, and M is a hydrogen atom, Na, or K.)
Inventors:
ISHIHARA TAKASHI (JP)
SUZAWA TOSHIYUKI (JP)
SUZUKI YASUAKI (JP)
MATSUMOTO YOSHIHIRO (JP)
AOYAMA SHIGEYUKI (JP)
SUZAWA TOSHIYUKI (JP)
SUZUKI YASUAKI (JP)
MATSUMOTO YOSHIHIRO (JP)
AOYAMA SHIGEYUKI (JP)
Application Number:
PCT/JP2013/075941
Publication Date:
April 24, 2014
Filing Date:
September 25, 2013
Export Citation:
Assignee:
JNC CORP (JP)
International Classes:
G01N30/88; B01D15/08; B01J20/281; B01J39/04; B01J39/20; B01J39/26; C07K1/18; C07K16/00
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Foreign References:
| US20110301330A1 | 2011-12-08 | |||
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Other References:
BIOTECHNOLOGY AND BIOENGINEERING, vol. 108, 2011, pages 1494 - 1508
J. CHROMATOGRAPHY A, vol. 1217, 2010, pages 216 - 224
J. CHROMATOGRAPHY A, vol. 1216, 2009, pages 902 - 909
L. FISCHER: "Seibutsukagaku Jikkenho (Biochemistry Experimental Method)", vol. 2, article "Gel chromatography"
JOURNAL OF CHROMATOGRAPHY A, vol. 1146, pages 202 - 215
JOURNAL OF POLYMER SCIENCE, 1958, pages 242 - 243
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, 2011, pages 2104 - 2119
J. CHROMATOGRAPHY A, vol. 1217, 2010, pages 216 - 224
J. CHROMATOGRAPHY A, vol. 1216, 2009, pages 902 - 909
L. FISCHER: "Seibutsukagaku Jikkenho (Biochemistry Experimental Method)", vol. 2, article "Gel chromatography"
JOURNAL OF CHROMATOGRAPHY A, vol. 1146, pages 202 - 215
JOURNAL OF POLYMER SCIENCE, 1958, pages 242 - 243
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, 2011, pages 2104 - 2119
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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