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Title:
CATION POLYMER CAPABLE OF REMOVING POSITIVE CHARGES BY MEANS OF OXIDATIVE RESPONSE, PREPARATION METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2017/063131
Kind Code:
A1
Abstract:
Disclosed are a cation polymer, serving as a gene delivery carrier, for removing positive charges by means of an oxidative response, a preparation method, and application. A charge reversal type gene delivery carrier is synthesized from 4-bromomethyl phenylboronic acid and N,N-diethylamino ethyl acrylate by means of quaternary amination. Compared with the prior art, different from a common quaternary amination carrier, the synthesized charge reversal type gene delivery carrier for oxidative response of the present invention has a large quantity of positive charges and can well coat a DNA, but the positive charges can be removed under the condition of intracellular oxidation when the charge reversal type gene delivery carrier enters a cell, a charge reverse is triggered, the positive charges turn to negative charges, and the DNA is quickly released for transfection. The carrier is efficient, low in toxicity, and good in application prospect.

Inventors:
SHEN, Youqing (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
LIU, Xin (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
TANG, Jianbin (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
LIU, Xiangrui (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
Application Number:
CN2015/091803
Publication Date:
April 20, 2017
Filing Date:
October 13, 2015
Export Citation:
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Assignee:
ZHEJIANG UNIVERSITY (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
International Classes:
C08F20/10; C08F8/32; C08F20/54; C08F26/02; C12N15/63
Domestic Patent References:
WO2004065440A22004-08-05
Foreign References:
CN101597349A2009-12-09
CN101659722A2010-03-03
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (Room 501, Zhu-Pin-Jin-Zuo No.1 Jing-Zhou Road, Xihu Distric, Hangzhou Zhejiang 3, 310013, CN)
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