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Patent Searching and Data


Title:
CATIONIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154288
Kind Code:
A1
Abstract:
Disclosed in the present invention are a cationic compound, a preparation method therefor and a use thereof. Provided by the present invention is a compound represented by formula I having a novel structure, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, the compound having a fast acting time, and having a long-acting local anesthetic effect after a single administration, wherein the time for which the sensory nerves are blocked is longer than the time for which the motor nerves are blocked; the compound has both a long-acting local anesthetic effect and a selective local anesthetic effect, significantly reducing the side effects of QX314 and QX314 compositions as well as cationic compounds having surfactant structural features, and being more safe; which is to say that the compound represented by formula I of the present invention and the pharmaceutically acceptable salt thereof may be used for the preparation of a safe drug having a long-acting local anesthetic effect and a selective local anesthetic effect, having the advantages of a long-acting local anesthetic effect, good local anesthetic selectivity, reduced nerve damage and greater safety.

Inventors:
LIU, Jin (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
KE, Bowen (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
ZHANG, Wensheng (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
YANG, Jun (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
TANG, Lei (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
Application Number:
CN2019/074276
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
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Assignee:
WEST CHINA HOSPITAL, SICHUAN UNIVERSITY (No.37, Guoxue Xiang Wuhou District, Chengdu Sichuan 1, 610041, CN)
International Classes:
C07D273/08; A61K31/16; A61P23/02; C07C237/04; C07C237/34; C07D205/04; C07D211/00; C07D273/00
Foreign References:
CN1295558A2001-05-16
CN103601650A2014-02-26
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (The Yiguanmiao Post Office Box A-42, Hi-Tech ZoneChengdu, Sichuan 1, 610041, CN)
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