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Patent Searching and Data


Title:
CATIONIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154288
Kind Code:
A1
Abstract:
Disclosed in the present invention are a cationic compound, a preparation method therefor and a use thereof. Provided by the present invention is a compound represented by formula I having a novel structure, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, the compound having a fast acting time, and having a long-acting local anesthetic effect after a single administration, wherein the time for which the sensory nerves are blocked is longer than the time for which the motor nerves are blocked; the compound has both a long-acting local anesthetic effect and a selective local anesthetic effect, significantly reducing the side effects of QX314 and QX314 compositions as well as cationic compounds having surfactant structural features, and being more safe; which is to say that the compound represented by formula I of the present invention and the pharmaceutically acceptable salt thereof may be used for the preparation of a safe drug having a long-acting local anesthetic effect and a selective local anesthetic effect, having the advantages of a long-acting local anesthetic effect, good local anesthetic selectivity, reduced nerve damage and greater safety.

Inventors:
LIU JIN (CN)
KE BOWEN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
TANG LEI (CN)
Application Number:
CN2019/074276
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
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Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07D273/08; A61K31/16; A61P23/02; C07C237/04; C07C237/34; C07D205/04; C07D211/00; C07D273/00
Foreign References:
CN1295558A2001-05-16
CN103601650A2014-02-26
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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