Title:
CATIONIC LIPID COMPOUND AND COMPOSITION FOR DELIVERY OF NUCLEIC ACID, AND USE
Document Type and Number:
WIPO Patent Application WO/2023/246747
Kind Code:
A1
Abstract:
Provided in the present invention are a cationic lipid compound and a composition for delivery of a nucleic acid, and the use. The compound is represented by the following formula (I). Further provided in the present invention are the use of a nano-lipid particle using the compound as a key component in the delivery of a nucleic acid; a component containing a delivery carrier; a preparation method; and a usage method.
Inventors:
HU YONG (CN)
LI YAFEI (CN)
HU ZHAOYU (CN)
LI YAFEI (CN)
HU ZHAOYU (CN)
Application Number:
PCT/CN2023/101290
Publication Date:
December 28, 2023
Filing Date:
June 20, 2023
Export Citation:
Assignee:
SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD (CN)
WUHAN RHEGEN BIOTECHNOLOGY CO LTD (CN)
WUHAN RHEGEN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C229/12; A61K9/127; A61K31/7088; A61K31/713; A61K47/18; A61K47/24; A61K47/28; A61P11/00; A61P31/14; C07C219/06; C07C229/16; C07C323/12; C07C323/52; C07D295/13
Foreign References:
| CN114773217A | 2022-07-22 | |||
| CN113185421A | 2021-07-30 | |||
| CN114380724A | 2022-04-22 | |||
| CN108368028A | 2018-08-03 | |||
| CN113999128A | 2022-02-01 | |||
| CN112979483A | 2021-06-18 | |||
| CN110799492A | 2020-02-14 | |||
| CN114380724A | 2022-04-22 | |||
| CN114380724A | 2022-04-22 |
Other References:
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "7,10,18,21-Tetraoxa-14-azahepta cosane-12,16-diol, 14-(2-hydroxyethyl)-9,19-di methyl-", XP093119260, retrieved from STN Database accession no. 66928-03-8
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "9,12,20,23-Tetraoxa-16-azahentri acontane-14,18-diol, 16-(2-hydroxyethyl)-11,21-di methyl-", XP093119258, retrieved from STN Database accession no. 66853-93-8
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "8,11,19,22-Tetraoxa-15-azanona cosane-13,17-diol, 15-(2-hydroxyethyl)-10,20-di methyl-", XP093119256, retrieved from STN Database accession no. 66853-90-5
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "6,9,17,20-Tetraoxa-13-azapentac osane-11,15-diol, 13-(2-hydroxyethyl)-8,18-di methyl- ", XP093119253, retrieved from STN Database accession no. 65212-59-1
DATABASE Regsitry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "5,8,16,19-Tetraoxa-12-azatricosa ne-10,14-diol, 12-(2-hydroxyethyl)-7,17-di methyl-", XP093119250, retrieved from STN Database accession no. 65212-57-9
"Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", MOL THER NUCLEIC ACIDS, vol. 15, 2019, pages 1 - 11
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "9,12,20,23-Tetraoxa-16-azahentri acontane-14,18-diol, 16-(2-hydroxyethyl)-11,21-di methyl-", XP093119258, retrieved from STN Database accession no. 66853-93-8
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "8,11,19,22-Tetraoxa-15-azanona cosane-13,17-diol, 15-(2-hydroxyethyl)-10,20-di methyl-", XP093119256, retrieved from STN Database accession no. 66853-90-5
DATABASE Registry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "6,9,17,20-Tetraoxa-13-azapentac osane-11,15-diol, 13-(2-hydroxyethyl)-8,18-di methyl- ", XP093119253, retrieved from STN Database accession no. 65212-59-1
DATABASE Regsitry CAS; 16 November 1984 (1984-11-16), ANONYMOUS : "5,8,16,19-Tetraoxa-12-azatricosa ne-10,14-diol, 12-(2-hydroxyethyl)-7,17-di methyl-", XP093119250, retrieved from STN Database accession no. 65212-57-9
"Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", MOL THER NUCLEIC ACIDS, vol. 15, 2019, pages 1 - 11
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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