Title:
CATIONIC LIPID COMPOUND FOR NUCLEIC ACID DELIVERY, COMPOSITION AND USE
Document Type and Number:
WIPO Patent Application WO/2023/246074
Kind Code:
A1
Abstract:
Provided in the present invention are a cationic lipid compound used for nucleic acid delivery, a composition and a use. The compound is as shown in the following formula (I). Further provided in the present invention are the use of the compound as a key component in nucleic acid delivery via nano-lipid particles, a component containing a delivery vector, a preparation method and a use method.
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Inventors:
HU YONG (CN)
LI YAFEI (CN)
HU ZHAOYU (CN)
LI YAFEI (CN)
HU ZHAOYU (CN)
Application Number:
PCT/CN2022/143764
Publication Date:
December 28, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD (CN)
WUHAN RHEGEN BIOTECHNOLOGY CO LTD (CN)
WUHAN RHEGEN BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C229/12; A61K9/127; A61K31/7088; A61K31/713; A61K47/18; A61K47/24; A61K47/28; A61P11/00; A61P31/14; C07C219/06; C07C229/16; C07C323/12; C07C323/52; C07D295/13
Foreign References:
| CN114773217A | 2022-07-22 | |||
| CN113185421A | 2021-07-30 | |||
| CN114380724A | 2022-04-22 | |||
| CN108368028A | 2018-08-03 | |||
| CN113999128A | 2022-02-01 | |||
| CN112979483A | 2021-06-18 | |||
| CN110799492A | 2020-02-14 |
Other References:
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 7,10,18,21-Tetraoxa-14-azaheptacosane-12,16-diol, 14-(2-hydroxyethyl)-9,19-dimethyl- (CA INDEX NAME)", XP093121430, retrieved from STNext Database accession no. 66928-03-8
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 9,12,20,23-Tetraoxa-16-azahentriacontane-14,18-diol, 16-(2-hydroxyethyl)-11,21-dimethyl- (CA INDEX NAME)", XP093121431, retrieved from STNext Database accession no. 66853-93-8
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 8,11,19,22-Tetraoxa-15-azanonacosane-13,17-diol, 15-(2-hydroxyethyl)-10,20-dimethyl- (CA INDEX NAME)", XP093121433, retrieved from STNext Database accession no. 66853-90-5
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 6,9,17,20-Tetraoxa-13-azapentacosane-11,15-diol, 13-(2-hydroxyethyl)-8,18-dimethyl- (CA INDEX NAME)", XP093121435, retrieved from STNext Database accession no. 65212-59-1
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 5,8,16,19-Tetraoxa-12-azatricosane-10,14-diol, 12-(2-hydroxyethyl)-7,17-dimethyl- (CA INDEX NAME)", XP093121436, retrieved from STNext Database accession no. 65212-57-9
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 9,12,20,23-Tetraoxa-16-azahentriacontane-14,18-diol, 16-(2-hydroxyethyl)-11,21-dimethyl- (CA INDEX NAME)", XP093121431, retrieved from STNext Database accession no. 66853-93-8
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 8,11,19,22-Tetraoxa-15-azanonacosane-13,17-diol, 15-(2-hydroxyethyl)-10,20-dimethyl- (CA INDEX NAME)", XP093121433, retrieved from STNext Database accession no. 66853-90-5
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 6,9,17,20-Tetraoxa-13-azapentacosane-11,15-diol, 13-(2-hydroxyethyl)-8,18-dimethyl- (CA INDEX NAME)", XP093121435, retrieved from STNext Database accession no. 65212-59-1
DATABASE Registry 16 November 1984 (1984-11-16), ANONYMOUS : " 5,8,16,19-Tetraoxa-12-azatricosane-10,14-diol, 12-(2-hydroxyethyl)-7,17-dimethyl- (CA INDEX NAME)", XP093121436, retrieved from STNext Database accession no. 65212-57-9
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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