Title:
CATIONIC LIPID
Document Type and Number:
WIPO Patent Application WO/2019/131580
Kind Code:
A1
Abstract:
[Problem] To provide a cationic lipid usable for delivering a nucleic acid to cytoplasm.
[Solution] The cationic lipid of the present invention is, for example, a compound represented by formula (1) or a pharmacologically acceptable salt thereof.
[In formula (1), L1 and L2 each independently represent a C3-10 alkylene group; R1 and R2 each independently represent a C4-24 alkyl or C4-24 alkenyl group; R3 represents a C1-3 alkyl group; and X1 represents a single bond or –CO-O-.]
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Inventors:
SUZUKI YUTA (JP)
TAKAHASHI YOSHINORI (JP)
TAKAHASHI YOSHINORI (JP)
Application Number:
PCT/JP2018/047440
Publication Date:
July 04, 2019
Filing Date:
December 25, 2018
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07D207/16; A61K31/7088; A61K31/713; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K48/00; A61P43/00
Domestic Patent References:
| WO2016104580A1 | 2016-06-30 | |||
| WO2015105131A1 | 2015-07-16 | |||
| WO2015095351A1 | 2015-06-25 | |||
| WO2012061259A2 | 2012-05-10 | |||
| WO2011153493A2 | 2011-12-08 | |||
| WO2013158579A1 | 2013-10-24 | |||
| WO2015095346A1 | 2015-06-25 | |||
| WO2017222016A1 | 2017-12-28 | |||
| WO2010144740A1 | 2010-12-16 | |||
| WO2011153493A2 | 2011-12-08 | |||
| WO2013086354A1 | 2013-06-13 | |||
| WO2013158579A1 | 2013-10-24 | |||
| WO2015095346A1 | 2015-06-25 | |||
| WO2016104580A1 | 2016-06-30 | |||
| WO2014089239A1 | 2014-06-12 |
Other References:
See also references of EP 3733647A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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