CATIONIZED HYALURONIC ACID OR SALT THEREOF, AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2023/125790

A1

Disclosed in the present invention are a cationized hyaluronic acid or a salt thereof, and a preparation method therefor. Carboxyl groups of the cationized hyaluronic acid or the salt thereof are at least partially linked to a quaternary ammonium salt-containing cationic group in the form of an ester bond, and cationically modify a hyaluronic acid or a salt thereof at carboxyl sites of the hyaluronic acid or the salt thereof; and a cationization reagent is subjected to ring opening under an acidic condition, and then is covalently linked to the carboxyl groups of the hyaluronic acid or the salt thereof by means of the ester bond. The obtained cationized hyaluronic acid or the salt thereof can effectively reduce the electrostatic interaction of anions and cations in molecules, has good compatibility, can be mixed with substances containing anions and amphoteric ions and does not precipitate or agglomerate, and is excellent in adsorption effect.

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WEI JIAN (CN)
GUO XUEPING (CN)
KANG JING (CN)
WANG CHENGSHAN (CN)
WANG HAO (CN)
ZHU LIANMING (CN)

PCT/CN2022/143333

July 06, 2023

December 29, 2022

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BLOOMAGE BIOTECHNOLOGY CORP LTD (CN)
DONGYING FIRST BIOCHEM IND CO LTD (CN)

C08B37/08

CN101715457A	2010-05-26
JP2008266258A	2008-11-06
CN108484794A	2018-09-04
JP2010037228A	2010-02-18

BEIJING TANGSONG IP FIRM (CN)

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