Title:
CBL-B MODULATORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/272248
Kind Code:
A9
Abstract:
The invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of a variety of Cbl-b-mediated diseases, disorders or conditions, associated with modulating the immune system implicating Cbl-b. Compounds are also useful for the study of Cbl-b enzymes in biological and pathological phenomena; the study of ubiquitination occurring in bodily tissues; and the comparative evaluation of new Cbl-b inhibitors or other regulators of cell cycle, DNA repair, differentiation, and innate and adaptive immunity in vitro or in vivo.
Inventors:
LEIT DE MORADEI SILVANA MARCEL (US)
WEST ANGELA V (US)
BAKER THOMAS (GB)
ARREGUI JOKIN CARRILLO (GB)
CASTAGNA DIANA (GB)
GREENWOOD JEREMY ROBERT (US)
RAFI SALMA (US)
MCROBB FIONA (US)
ZHANG YAN (US)
WEST ANGELA V (US)
BAKER THOMAS (GB)
ARREGUI JOKIN CARRILLO (GB)
CASTAGNA DIANA (GB)
GREENWOOD JEREMY ROBERT (US)
RAFI SALMA (US)
MCROBB FIONA (US)
ZHANG YAN (US)
Application Number:
PCT/US2022/073060
Publication Date:
June 01, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
NIMBUS CLIO INC (US)
International Classes:
C07D207/30; A61K31/44; C07D213/02
Attorney, Agent or Firm:
REID, Andrea L.C. et al. (US)
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