Title:
A CD19-BASED CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/161796
Kind Code:
A1
Abstract:
The present application provides a chimeric antigen receptor and application thereof. The chimeric antigen receptor comprises an antigen-binding domain, a transmembrane domain, a costimulatory signal transduction region, a CD3ζ signal transduction domain, and an inducible suicide fusion domain in tandem arrangement; wherein the antigen-binding domain binds to a tumor surface antigen and the tumor surface antigen is CD19.
Inventors:
ZHANG RUI (CN)
Application Number:
PCT/CN2019/076050
Publication Date:
August 29, 2019
Filing Date:
February 25, 2019
Export Citation:
Assignee:
BEIJING MEIKANG GENO IMMUNE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; A61P35/02; C12N5/10; C12N15/867
Foreign References:
| CN108383914A | 2018-08-10 | |||
| CN106535925A | 2017-03-22 | |||
| CN107245106A | 2017-10-13 | |||
| CN107400168A | 2017-11-28 | |||
| CN107312091A | 2017-11-03 | |||
| US20170137515A1 | 2017-05-18 | |||
| CN107312097A | 2017-11-03 |
Other References:
See also references of EP 3740511A4
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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