Title:
CD4-MIMETIC SMALL MOLECULES SENSITIZE HUMAN IMMUNODEFICIENCY VIRUS TO VACCINE-ELICITED ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2015/120440
Kind Code:
A3
Abstract:
Described herein are methods of generating a protein binding domain that specifically binds to gp120 in a specific conformational state, comprising contacting gp120 with a CD4-mimetic compound, thereby forming gp120 in the specific conformational state; and generating antibodies to gp120 in the specific conformation state. Relatedly, the disclosure also describes methods of neutralizing HIV- 1, comprising contacting HIV-1 with an effective amount of a CD4-mimetic compound, thereby forming HIV-1 having gp120 in a specific conformational state; and contacting the HIV-1 in the specific conformational state with an antibody.
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Inventors:
SODROSKI JOSEPH (US)
MADANI NAVID (US)
PRINCIOTTO AMY M (US)
SCHON AME (US)
LALONDE JUDITH M (US)
FREIRE ERNESTO (US)
SMITH AMOS B III (US)
WYATT RICHARD T (US)
PARK JONGWOO (KR)
COURTER JOEL R (US)
JONES DAVID M (US)
MADANI NAVID (US)
PRINCIOTTO AMY M (US)
SCHON AME (US)
LALONDE JUDITH M (US)
FREIRE ERNESTO (US)
SMITH AMOS B III (US)
WYATT RICHARD T (US)
PARK JONGWOO (KR)
COURTER JOEL R (US)
JONES DAVID M (US)
Application Number:
PCT/US2015/015182
Publication Date:
November 12, 2015
Filing Date:
February 10, 2015
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
UNIV JOHNS HOPKINS (US)
BRYN MAWR COLLEGE (US)
UNIV PENNSYLVANIA (US)
SCRIPPS RESEARCH INST (US)
UNIV JOHNS HOPKINS (US)
BRYN MAWR COLLEGE (US)
UNIV PENNSYLVANIA (US)
SCRIPPS RESEARCH INST (US)
International Classes:
A01N37/00; A61K31/16; A61K31/185
Domestic Patent References:
| WO2013090696A1 | 2013-06-20 |
Foreign References:
| US6030772A | 2000-02-29 | |||
| US7811580B2 | 2010-10-12 |
Other References:
"HIV-1 gp120 Monoclonal Antibody (48d) Data Sheet", NIH AIDS REAGENT PROGRAM., 2013, pages 1 - 2, XP055236991, Retrieved from the Internet
DEY, AK ET AL.: "Elicitation Of Neutralizing Antibodies Directed Against CD 4-Induced Epitope(s) Using a CD 4 Mimetic Cross-Linked To A HIV-1 Envelope Glycoprotein.", PLOS ONE., vol. 7, no. 1, 24 January 2012 (2012-01-24), pages 1 - 13, XP055236992
DEY, AK ET AL.: "Elicitation Of Neutralizing Antibodies Directed Against CD 4-Induced Epitope(s) Using a CD 4 Mimetic Cross-Linked To A HIV-1 Envelope Glycoprotein.", PLOS ONE., vol. 7, no. 1, 24 January 2012 (2012-01-24), pages 1 - 13, XP055236992
Attorney, Agent or Firm:
SMITH, DeAnn, F. et al. (Seaport West155 Seaport Blvd, Boston MA, US)
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