Title:
CD40 BIDIRECTIONAL-ACTIVATED COSTIMULATORY MOLECULE RECEPTOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/129047
Kind Code:
A1
Abstract:
The present invention relates to the field of cytobiology and immunology, and relates to a CD40 bidirectional-activated costimulatory molecule receptor, and a use thereof. Specifically, the present invention relates to a bidirectional-activated costimulatory molecule receptor, sequentially comprising the following elements from terminal N to terminal C: an optional signal peptide, a CD40 activated single-chain antibody, an extracellular hinge region, a transmembrane region, and an intracellular costimulatory signal molecule. When the CD40 bidirectional-activated costimulatory molecule receptor and a first-generation CAR-T comprising a first signal are both used to modify a T-cell together, a strong clustering effect may be generated to kill and wound tumor cells. Moreover, the effect of bidirectional activation is merely limited to T-cells in contact with each other, and no strong T-cell immune response may be triggered as it does when the activated antibody of CD40 is injected, which may cause potential severe toxic and side effects.
Inventors:
QIAN QIJUN (CN)
JIN HUAJUN (CN)
XU HUIMIN (CN)
LIU XIANGZHEN (CN)
LI LINFANG (CN)
WANG CHAO (CN)
JIN HUAJUN (CN)
XU HUIMIN (CN)
LIU XIANGZHEN (CN)
LI LINFANG (CN)
WANG CHAO (CN)
Application Number:
PCT/CN2018/123859
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
Assignee:
SHANGHAI CELL THERAPY RES INST (CN)
SHANGHAI CELL THERAPY GROUP CO LTD (CN)
SHANGHAI CELL THERAPY GROUP CO LTD (CN)
International Classes:
C07K19/00; A61P35/00; C12N5/10; C12N15/62; C12N15/63
Foreign References:
| CN103483453A | 2014-01-01 | |||
| CN105177031A | 2015-12-23 |
Other References:
KEVIN J CURRAN: "Enhancing Antitumor Efiicacy of Chimeric Antigen Rece- ptor T Cells Through Constitutive CD 40L Expression", THE AMERICAN SOCIETY OF GENE & CELL THERAPY, vol. 25, no. 4, 30 April 2015 (2015-04-30), pages 769 - 778
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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