Title:
CD40L-SPECIFIC TN3-DERIVED SCAFFOLDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/055745
Kind Code:
A3
Abstract:
The present invention provides Tenascin-3 Fnlll domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.
Inventors:
COYLE ANTHONY (US)
BACA MANUEL (US)
THISTED THOMAS (US)
DRABIC STACEY (US)
GRINBERG LUBA (US)
NOVARRA SHABAZZ (US)
OGANESYAN VAHEH (US)
HERBST RONALD (US)
SPENCER DAVID KENNETH (US)
BACA MANUEL (US)
THISTED THOMAS (US)
DRABIC STACEY (US)
GRINBERG LUBA (US)
NOVARRA SHABAZZ (US)
OGANESYAN VAHEH (US)
HERBST RONALD (US)
SPENCER DAVID KENNETH (US)
Application Number:
PCT/US2012/059477
Publication Date:
August 01, 2013
Filing Date:
October 10, 2012
Export Citation:
Assignee:
MEDIMMUNE LLC (US)
International Classes:
A61K38/05; C07K4/00; G16B45/00
Domestic Patent References:
| WO2011051466A1 | 2011-05-05 |
Foreign References:
| US20100298541A1 | 2010-11-25 | |||
| US20100098730A1 | 2010-04-22 | |||
| US20080004206A1 | 2008-01-03 | |||
| US20090176654A1 | 2009-07-09 |
Other References:
DATABASE GENBANK [online] 9 October 2011 (2011-10-09), "CD40 ligand [Homo sapiens]", XP003033826, Database accession no. NP_000065
Attorney, Agent or Firm:
KREPPEL, Lisa (LLCOne Medimmune Wa, Gaithersburg MD, US)
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