Title:
CD47 EXPRESSION INHIBITOR AND USE THEREOF IN COMBINATION WITH IMMUNOTHERAPEUTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2022/121236
Kind Code:
A1
Abstract:
Disclosed in the present invention are a CD47 expression inhibitor and a use thereof in combination with an immunotherapeutic drug. The CD47 expression inhibitor uses a compound represented by formula IOX1 or ROX or a pharmaceutically acceptable salt thereof as an active ingredient, and IOX1 or ROX can improve the immunotherapeutic effect by means of down-regulation of the expression of CD47 in tumor cells. Also disclosed in the present invention is a method for using the CD47 expression inhibitor in combination with a therapeutic antibody, which further improves the therapeutic effect.
Inventors:
SHEN YOUQING (CN)
LIU JING (CN)
ZHAO ZHIHAO (CN)
LIU JING (CN)
ZHAO ZHIHAO (CN)
Application Number:
PCT/CN2021/094253
Publication Date:
June 16, 2022
Filing Date:
May 18, 2021
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K31/47; A61K31/472; A61P35/00
Domestic Patent References:
| WO2017190009A1 | 2017-11-02 | |||
| WO2020055946A1 | 2020-03-19 | |||
| WO2017210608A1 | 2017-12-07 | |||
| WO2017194958A1 | 2017-11-16 | |||
| WO2020081987A1 | 2020-04-23 | |||
| WO2017011907A1 | 2017-01-26 |
Foreign References:
| CN112516141A | 2021-03-19 | |||
| JP2021024797A | 2021-02-22 |
Other References:
LONG GUANGFENG, CHEN HONGBING, WU MENGYING, LI YUANYUAN, GAO LING, HUANG SONGMING, ZHANG YUE, JIA ZHANJUN, XIA WEIWEI: "Antianemia Drug Roxadustat (FG-4592) Protects Against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways", FRONTIERS IN PHARMACOLOGY, vol. 11, XP055942038, DOI: 10.3389/fphar.2020.01191
YU YONG, SCHLEICH KOLJA, YUE BIN, JI SUJUAN, LOHNEIS PHILIPP, KEMPER KRISTEL, SILVIS MARK R., QUTOB NOUAR, VAN ROOIJEN ELLEN, WERN: "Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma", CANCER CELL, CELL PRESS, US, vol. 33, no. 2, 1 February 2018 (2018-02-01), US , pages 322 - 336.e8, XP055942040, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.01.002
YU YONG, SCHLEICH KOLJA, YUE BIN, JI SUJUAN, LOHNEIS PHILIPP, KEMPER KRISTEL, SILVIS MARK R., QUTOB NOUAR, VAN ROOIJEN ELLEN, WERN: "Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma", CANCER CELL, CELL PRESS, US, vol. 33, no. 2, 1 February 2018 (2018-02-01), US , pages 322 - 336.e8, XP055942040, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.01.002
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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