Title:
CD7-CAR-T CELL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160260
Kind Code:
A1
Abstract:
Disclosed in the present invention are a CD7-CAR-T cell, and a preparation method therefor and the use thereof, wherein the CD7-CAR-T cell contains an antibody targeting a CD7 antigen or an antigen-binding fragment thereof, and the antibody or antigen-binding fragment thereof contains heavy chain variable regions of complementarity-determining regions CDR1, CDR2 and CDR3 having amino acid sequences as shown in SEQ ID NOs: 12-14, and light chain variable regions of complementarity-determining regions CDR1, CDR2 and CDR3 having amino acid sequences as shown in SEQ ID NOs: 15-17. The antibody of the present invention and CD7-CAR based on the antibody fragment have extremely strong affinity to a CD7 antigen molecule. Moreover, a blocking molecule of the present invention can almost completely block the expression of the CD7 molecule on a cell surface without substantially affecting the normal expansion of T cells, thereby effectively avoiding the self-killing between CD7-CAR-T cells. In addition, the CD7-CAR-T cells of the present invention have a significant and specific killing effect on CD7-positive target cells, and provide beneficial CAR-T cells for the clinical application of cell therapy.
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Inventors:
XU ZHONGWEI (CN)
ZHANG HAIYAN (CN)
ZHANG HAIYAN (CN)
Application Number:
PCT/CN2023/070315
Publication Date:
August 31, 2023
Filing Date:
January 04, 2023
Export Citation:
Assignee:
ADVANCED BIOTHERAPEUTICS LTD (CN)
XU ZHONGWEI (CN)
XU ZHONGWEI (CN)
International Classes:
A61K39/00; C07K16/28; A61P35/00; A61P35/02; C07K19/00; C12N5/10; C12N15/13; C12N15/62; C12N15/867
Domestic Patent References:
| WO2017213979A1 | 2017-12-14 | |||
| WO2003051926A2 | 2003-06-26 |
Foreign References:
| CN114560943A | 2022-05-31 | |||
| CN114007699A | 2022-02-01 | |||
| CN104004095A | 2014-08-27 | |||
| CN110268049A | 2019-09-20 |
Attorney, Agent or Firm:
BEIJING ZERORICH IP FIRM (CN)
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