Title:
CD80 (B7-1) BINDING PEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/108432
Kind Code:
A2
Abstract:
Molecules that bind the CD80 (B7-1) ligand presented by Antigen Presenting Cells and thereby selectively inhibit costimulation of T cells. Various forms and preparations of these molecules may bind to the CD80 ligand under either or both in vivo or in vitro conditions. These molecules may be referred to as pseudo-receptors include polypeptides include polypeptides that incorporate the amino-acid sequence MQPPGC, and a retro-inverso peptide mimic that includes the D-amino acid sequence CGPPQM. These molecules have a propensity to adopt a polyproline type II helical conformation under physiological conditions. Uses for these molecules include studying the immune system, screening for other compounds that affect the immune system, or at least components of the immune system, and the treatment of autoimmune diseases such as multiple sclerosis, colitis (inflammatory bowel disease -IBD), rheumatoid arthritis, Crohn's disease, Sjorgren's syndrome, diabetes mellitus, and solid tissue transplant rejection.
Inventors:
SRINIVASAN MYTHILY (US)
Application Number:
PCT/US2005/011209
Publication Date:
November 17, 2005
Filing Date:
March 30, 2005
Export Citation:
Assignee:
UNIV INDIANA RES & TECH CORP (US)
SRINIVASAN MYTHILY (US)
SRINIVASAN MYTHILY (US)
International Classes:
C07K7/06; C07K7/08; C07K16/28; A61K38/00; (IPC1-7): C07K16/28
Foreign References:
| US20030091593A1 | 2003-05-15 | |||
| US20030147905A1 | 2003-08-07 |
Attorney, Agent or Firm:
Emanuele, John J. (Emhardt Moriarty, Mcnett & Henry LLP, Bank
One Center/Tower, Suite 3700, 111 Monument Circl, Indianapolis IN, US)
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