Title:
CDC25 PHOSPHATASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002009686
Kind Code:
A3
Abstract:
The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR<1>R<2> radical wherein R<1> and R<2> represent a hydrogen atom or an alkyl radical or R<1> and R<2> form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR<3>R<4>-, -O-, -S and NR<5>- radicals, R<3> and R<4> representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR<1>R<2> radical wherein R<1> and R<2> represent a hydrogen atom or an alkyl radical; B represents a -(CH2)i-(CO)- or -NH-CO-(CH2)n or -(CH2)p and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a -(CH2)q- or (CH2)j-CO-(CH2)r-, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T).
Inventors:
PREVOST GREGOIRE (FR)
BREZAK PANNETIER MARIE-CHRISTI (FR)
GALCERA CONTOUR MARIE-ODILE (FR)
THURIEAU CHRISTOPHE (FR)
GOUBIN-GRAMATICA FRANCOISE (FR)
DUCOMMUN BERNARD (FR)
LANCO CHRISTOPHE (FR)
BREZAK PANNETIER MARIE-CHRISTI (FR)
GALCERA CONTOUR MARIE-ODILE (FR)
THURIEAU CHRISTOPHE (FR)
GOUBIN-GRAMATICA FRANCOISE (FR)
DUCOMMUN BERNARD (FR)
LANCO CHRISTOPHE (FR)
Application Number:
PCT/FR2001/002443
Publication Date:
October 09, 2003
Filing Date:
July 26, 2001
Export Citation:
Assignee:
SOD CONSEILS RECH APPLIC (FR)
PREVOST GREGOIRE (FR)
BREZAK PANNETIER MARIE-CHRISTI (FR)
GALCERA CONTOUR MARIE-ODILE (FR)
THURIEAU CHRISTOPHE (FR)
GOUBIN-GRAMATICA FRANCOISE (FR)
DUCOMMUN BERNARD (FR)
LANCO CHRISTOPHE (FR)
PREVOST GREGOIRE (FR)
BREZAK PANNETIER MARIE-CHRISTI (FR)
GALCERA CONTOUR MARIE-ODILE (FR)
THURIEAU CHRISTOPHE (FR)
GOUBIN-GRAMATICA FRANCOISE (FR)
DUCOMMUN BERNARD (FR)
LANCO CHRISTOPHE (FR)
International Classes:
A61K31/04; A61K31/137; A61K31/166; A61K31/18; A61K31/222; A61K31/24; A61K31/381; A61K31/4164; A61K31/445; A61K31/495; A61K31/63; A61K31/661; A61K31/6615; A61P17/14; A61P21/00; A61P25/00; A61P25/28; A61P31/12; C07D295/12; A61P33/00; A61P35/00; A61P43/00; C07C69/157; C07C211/53; C07C215/78; C07C215/80; C07C217/84; C07C229/36; C07C235/66; C07C303/38; C07C311/08; C07C311/13; C07C311/21; C07C311/29; C07C311/37; C07D211/96; C07D233/84; C07D241/04; C07D295/135; C07D295/155; C07D295/192; C07D295/26; C07D333/22; C07D333/34; C07D333/38; C07F9/12; (IPC1-7): A61K31/137; A61K31/495; A61K31/381; A61P43/00; A61P17/14; A61P35/00; A61P33/00; A61P31/12; A61P25/28; A61P21/00; A61K31/166; A61K31/222; A61K31/661; A61K31/18; A61K31/4164; A61K31/63; C07C211/53; C07D295/155
Domestic Patent References:
| WO2000017190A2 | 2000-03-30 | |||
| WO1998042696A1 | 1998-10-01 | |||
| WO1995005363A1 | 1995-02-23 |
Foreign References:
| US4032635A | 1977-06-28 |
Other References:
BOURHIM, MUSTAPHA ET AL: "Design, anticonvulsive, and neurotoxic properties of retrobenzamides. N-(nitrophenyl)benzamides and N-(aminophenyl)benzamides", ARZNEIM.-FORSCH. (1999), 49(2), 81-87, XP000992843
C. YAMAGAMI ET AL.: "A Quantitative Structure-Activity Study of Anticonvulsant Phenylacetanilides", HEM. PHARM. BULL., vol. 32, no. 12, 1984, pages 5003 - 5009, XP002166155
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FUJISAWA PHARMACEUTICAL CO., LTD., JAPAN: "Preparation of biphenyl compounds as drugs", XP002166157, retrieved from STN Database accession no. 115:114130
"THE MERCK INDEX", 1996, MERCK & CO., INC, XP002166156
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; UMEZAWA, HAMAO ET AL: "Benzanilide derivatives", XP002166158, retrieved from STN Database accession no. 87:5662
R.A. COBURN ET AL.: "Potential Salicylamide Antiplaque Agents: In vitro Antibacterial Activity against Actinomyces viscosus", J. MED. CHEM., vol. 24, 1981, pages 1245 - 1249, XP000992845
C. YAMAGAMI ET AL.: "A Quantitative Structure-Activity Study of Anticonvulsant Phenylacetanilides", HEM. PHARM. BULL., vol. 32, no. 12, 1984, pages 5003 - 5009, XP002166155
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FUJISAWA PHARMACEUTICAL CO., LTD., JAPAN: "Preparation of biphenyl compounds as drugs", XP002166157, retrieved from STN Database accession no. 115:114130
"THE MERCK INDEX", 1996, MERCK & CO., INC, XP002166156
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; UMEZAWA, HAMAO ET AL: "Benzanilide derivatives", XP002166158, retrieved from STN Database accession no. 87:5662
R.A. COBURN ET AL.: "Potential Salicylamide Antiplaque Agents: In vitro Antibacterial Activity against Actinomyces viscosus", J. MED. CHEM., vol. 24, 1981, pages 1245 - 1249, XP000992845
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