Title:
CDK-INHIBITING PYRROLOPYRIMIDINONE CARBOXAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING LIVER CELL CANCER
Document Type and Number:
WIPO Patent Application WO/2012/060482
Kind Code:
A1
Abstract:
The present invention relates to a CDK-inhibiting pyrrolopyrimidinone carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating liver cell cancer, and the composition containing the pyrrolopyrimidinone carboxamide derivative of the present invention suppresses the cell growth of SNU-354 cell, which is a liver cancer stem cell in humans, by inhibiting CDK1 and CDK2, and induces cell apoptosis of the cell by inhibiting CDK7 and CDK 7, and thus can be effective in use for preventing or treating liver cell cancer.
Inventors:
LEE SEUNG KI (KR)
KIM BYEONG MOON (KR)
CHO SEUNG JU (KR)
KIM YOUNG JONG (KR)
KIM BYEONG MOON (KR)
CHO SEUNG JU (KR)
KIM YOUNG JONG (KR)
Application Number:
PCT/KR2010/007650
Publication Date:
May 10, 2012
Filing Date:
November 02, 2010
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
LEE SEUNG KI (KR)
KIM BYEONG MOON (KR)
CHO SEUNG JU (KR)
KIM YOUNG JONG (KR)
LEE SEUNG KI (KR)
KIM BYEONG MOON (KR)
CHO SEUNG JU (KR)
KIM YOUNG JONG (KR)
International Classes:
C07H19/14; A61K31/7068; A61P35/00
Foreign References:
| US20020035077A1 | 2002-03-21 | |||
| US20090117651A1 | 2009-05-07 |
Other References:
HAM Y.-M. ET AL.: "Xylocydine, a Novel Inhibitor of Cyclin-Dependent Kinases, Prevents the Tumor Necrosi: Factor-Related Apoptosis- Inducing Ligand-Induced Apoptotic Cell Death of SK-HEP-1 Cells", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 308, no. 2, 2004, pages 814 - 819, XP055089517
CHO S.-J. ET AL.: "Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo", CANCER LETTERS, vol. 287, 28 January 2010 (2010-01-28), pages 196 - 206, XP026824293
CHO S.-J. ET AL.: "Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo", CANCER LETTERS, vol. 287, 28 January 2010 (2010-01-28), pages 196 - 206, XP026824293
Attorney, Agent or Firm:
LEE, WON-HEE (KR)
이원희 (KR)
이원희 (KR)
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Claims: