Title:
CDK INHIBITOR AND POLYMORPH OF PHOSPHATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027825
Kind Code:
A1
Abstract:
The present application provides a polymorph of a compound of formula (A), i.e., N-(1-((4-((3S,5S)-3,5-dimethylpiperazine-1-yl)phenyl)sulfonyl)piperidin-4-yl)-4-((S)-tetrahydrofuran-3-yl)oxy)-5(trifluoromethyl)pyrimidine-2-amine, and a polymorph of a phosphate of the compound of formula (A). A crystalline form provided by the present application has good chemical stability and physical stability, and low hygroscopicity, is less affected by temperature, humidity, and illumination, and facilitates storage and preparation development.
Inventors:
JIANG CHEN (CN)
FU QIANG (CN)
FU QIANG (CN)
Application Number:
PCT/CN2023/111237
Publication Date:
February 08, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
QILU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D405/14; A61K31/506; A61P35/00; C07D401/14
Domestic Patent References:
| WO2022166793A1 | 2022-08-11 | |||
| WO2020180959A1 | 2020-09-10 | |||
| WO2021170076A1 | 2021-09-02 |
Foreign References:
| CN101490041A | 2009-07-22 | |||
| US20210047294A1 | 2021-02-18 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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