Title:
CDK2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/155941
Kind Code:
A1
Abstract:
The invention provides a compound represented by structural formula (I), or a pharmaceutically acceptable salt, or a stereoisomer thereof useful for treating a disease or disorder associated with CDK2.
Inventors:
HE HU (CN)
ZHONG WENGE (US)
ZHONG WENGE (US)
Application Number:
PCT/CN2021/073515
Publication Date:
July 28, 2022
Filing Date:
January 25, 2021
Export Citation:
Assignee:
QILU REGOR THERAPEUTICS INC (CN)
International Classes:
C07D471/08; A61K31/506; A61P35/00; C07D417/14; C07D487/08; C07D498/08
Domestic Patent References:
| WO2003015776A1 | 2003-02-27 | |||
| WO2015058163A2 | 2015-04-23 | |||
| WO2020180959A1 | 2020-09-10 | |||
| WO2006056399A2 | 2006-06-01 | |||
| WO2004005281A1 | 2004-01-15 | |||
| WO2003037347A1 | 2003-05-08 | |||
| WO2003099771A2 | 2003-12-04 | |||
| WO2004046120A2 | 2004-06-03 | |||
| WO2000009495A1 | 2000-02-24 | |||
| WO2005028444A1 | 2005-03-31 | |||
| WO2004080980A1 | 2004-09-23 | |||
| WO2004056786A2 | 2004-07-08 | |||
| WO2003024967A2 | 2003-03-27 | |||
| WO2001064655A1 | 2001-09-07 | |||
| WO2000053595A1 | 2000-09-14 | |||
| WO2001014402A1 | 2001-03-01 | |||
| WO2009085185A1 | 2009-07-09 | |||
| WO2012129344A1 | 2012-09-27 | |||
| WO2011101409A1 | 2011-08-25 | |||
| WO2003062236A1 | 2003-07-31 | |||
| WO2010075074A1 | 2010-07-01 | |||
| WO2012061156A1 | 2012-05-10 |
Foreign References:
| US5521184A | 1996-05-28 | |||
| USPP60578491P |
Other References:
EKHOLM, S. V.S. I. REED, CURR OPIN CELL BIOL, vol. 12, no. 6, 2000, pages 676 - 84
XU, X. ET AL., BIOCHEMISTRY, vol. 38, no. 27, 1999, pages 8713 - 22
KEYOMARSI, K. ET AL., NENGL J MED, vol. 347, no. 20, 2002, pages 1566 - 75
NAKAYAMA, N. ET AL., CANCER, vol. 116, no. 11, 2010, pages 2621 - 34
AU-YEUNG, G. ET AL., CLIN CANCER RES, vol. 23, no. 7, 2017, pages 1862 - 1874
ROSEN, D. G. ET AL., CANCER, vol. 106, no. 9, 2006, pages 1925 - 32
SCALTRITI, M. ET AL., PROC NATL ACAD SCI USA, vol. 108, no. 9, 2011, pages 3761 - 6
HERRERA-ABREU, M. T. ET AL., CANCER RES, vol. 76, no. 8, 2016, pages 2301 - 13
CHEN, Y N. ET AL., PROC NATL ACAD SCI USA, vol. 96, no. 8, 1999, pages 4325 - 9
MENDOZA, N. ET AL., CANCER RES, vol. 63, no. 5, 2003, pages 1020 - 4
CICENAS ET AL., CANCERS (BASEL, vol. 6, no. 4, 2014, pages 2224 - 42
S. M. BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
SMITH, ROGER M.: "Chromatographic Science Series", vol. 75, 1998, LOUGHBOROUGH UNIVERSITY, article "Supercritical Fluid Chromatography with Packed Columns", pages: 223 - 249
FINNINMORGAN, J. PHARM. SCI., vol. 88, 1999, pages 955 - 958
HOOVER, JOHN E.: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING CO.
"Pharmaceutical Dosage Forms", 1980, MARCEL DECKER
THOMAS SORRELL: "Handbook of Pharmaceutical Excipients", 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
MOLENAAR ET AL., PROC NATL ACAD SCI USA, vol. 106, no. 31, pages 12968 - 12973
HU, S. ET AL., MOL CANCER THER, vol. 14, no. 11, 2015, pages 2576 - 85
TAKADA ET AL., CANCER RES, vol. 77, no. 18, 2017, pages 4881 - 4893
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", 1996, MEDICAL ECONOMICS COMPANY
MORRISONBOYD: "Handbook of Chemistry and Physics"
XU, X. ET AL., BIOCHEMISTRY, vol. 38, no. 27, 1999, pages 8713 - 22
KEYOMARSI, K. ET AL., NENGL J MED, vol. 347, no. 20, 2002, pages 1566 - 75
NAKAYAMA, N. ET AL., CANCER, vol. 116, no. 11, 2010, pages 2621 - 34
AU-YEUNG, G. ET AL., CLIN CANCER RES, vol. 23, no. 7, 2017, pages 1862 - 1874
ROSEN, D. G. ET AL., CANCER, vol. 106, no. 9, 2006, pages 1925 - 32
SCALTRITI, M. ET AL., PROC NATL ACAD SCI USA, vol. 108, no. 9, 2011, pages 3761 - 6
HERRERA-ABREU, M. T. ET AL., CANCER RES, vol. 76, no. 8, 2016, pages 2301 - 13
CHEN, Y N. ET AL., PROC NATL ACAD SCI USA, vol. 96, no. 8, 1999, pages 4325 - 9
MENDOZA, N. ET AL., CANCER RES, vol. 63, no. 5, 2003, pages 1020 - 4
CICENAS ET AL., CANCERS (BASEL, vol. 6, no. 4, 2014, pages 2224 - 42
S. M. BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
SMITH, ROGER M.: "Chromatographic Science Series", vol. 75, 1998, LOUGHBOROUGH UNIVERSITY, article "Supercritical Fluid Chromatography with Packed Columns", pages: 223 - 249
FINNINMORGAN, J. PHARM. SCI., vol. 88, 1999, pages 955 - 958
HOOVER, JOHN E.: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING CO.
"Pharmaceutical Dosage Forms", 1980, MARCEL DECKER
THOMAS SORRELL: "Handbook of Pharmaceutical Excipients", 1999, AMERICAN PHARMACEUTICAL ASSOCIATION
MOLENAAR ET AL., PROC NATL ACAD SCI USA, vol. 106, no. 31, pages 12968 - 12973
HU, S. ET AL., MOL CANCER THER, vol. 14, no. 11, 2015, pages 2576 - 85
TAKADA ET AL., CANCER RES, vol. 77, no. 18, 2017, pages 4881 - 4893
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", 1996, MEDICAL ECONOMICS COMPANY
MORRISONBOYD: "Handbook of Chemistry and Physics"
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
Download PDF: