Title:
CDK9 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/028556
Kind Code:
A1
Abstract:
Provided are a compound of formula (I) or a tautomer, a mesomer, a raceme, an enantiomer, a diastereoisomer, or a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of drugs for diseases mediated by CDK9.
Inventors:
PENG ZUOZHONG (CN)
JIA JILIN (CN)
HU JIAQI (CN)
CUI QIAN (CN)
WU YIZHOU (CN)
YI YUNFEI (CN)
CHEN QIUHONG (CN)
WANG JIE (CN)
JIA JILIN (CN)
HU JIAQI (CN)
CUI QIAN (CN)
WU YIZHOU (CN)
YI YUNFEI (CN)
CHEN QIUHONG (CN)
WANG JIE (CN)
Application Number:
PCT/CN2021/111073
Publication Date:
February 10, 2022
Filing Date:
August 06, 2021
Export Citation:
Assignee:
PHARMABLOCK SCIENCES NANJING INC (CN)
International Classes:
C07D401/12; A61K31/44; A61K31/497; A61K31/501; A61P35/00; C07D213/74; C07D401/00; C07D401/14; C07D417/14
Domestic Patent References:
| WO2019154177A1 | 2019-08-15 | |||
| WO2017001354A1 | 2017-01-05 |
Foreign References:
| CN103562184A | 2014-02-05 | |||
| CN104822380A | 2015-08-05 | |||
| CN102143953A | 2011-08-03 | |||
| CN101568529A | 2009-10-28 |
Other References:
GAO JIADI, FANG CHENG, XIAO ZHIYAN, HUANG LI, CHEN CHIN-HO, WANG LI-TING, LEE KUO-HSIUNG: "Discovery of novel 5-fluoro- N 2 , N 4 -diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9", MEDCHEMCOMM, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 6, no. 3, 9 March 2015 (2015-03-09), United Kingdom , pages 444 - 454, XP055814528, ISSN: 2040-2503, DOI: 10.1039/C4MD00412D
ALISON J. HOLE, SONJA BAUMLI, HAO SHAO, SHENHUA SHI, SHILIANG HUANG, CHRIS PEPPER, PETER M. FISCHER, SHUDONG WANG, JANE A. ENDICOT: "Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 3, 14 February 2013 (2013-02-14), US , pages 660 - 670, XP055145617, ISSN: 0022-2623, DOI: 10.1021/jm301495v
WANG, S. ; GRIFFITHS, G. ; MIDGLEY, C.A. ; BARNETT, A.L. ; COOPER, M. ; GRABAREK, J. ; INGRAM, L. ; JACKSON, W. ; KONTOPIDIS, G. ;: "Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents", CHEMISTRY & BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 10, 29 October 2010 (2010-10-29), GB , pages 1111 - 1121, XP027451262, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2010.07.016
JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 2, 2017, pages 233 - 241
ALISON J. HOLE, SONJA BAUMLI, HAO SHAO, SHENHUA SHI, SHILIANG HUANG, CHRIS PEPPER, PETER M. FISCHER, SHUDONG WANG, JANE A. ENDICOT: "Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 3, 14 February 2013 (2013-02-14), US , pages 660 - 670, XP055145617, ISSN: 0022-2623, DOI: 10.1021/jm301495v
WANG, S. ; GRIFFITHS, G. ; MIDGLEY, C.A. ; BARNETT, A.L. ; COOPER, M. ; GRABAREK, J. ; INGRAM, L. ; JACKSON, W. ; KONTOPIDIS, G. ;: "Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents", CHEMISTRY & BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 17, no. 10, 29 October 2010 (2010-10-29), GB , pages 1111 - 1121, XP027451262, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2010.07.016
JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 2, 2017, pages 233 - 241
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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