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Title:
CEFATHIAMIDINE NOVEL CRYSTAL COMPOUND USING PARTICLE PROCESS CRYSTAL PRODUCT MOLECULAR ASSEMBLY AND MORPHOLOGY OPTIMISATION TECHNOLOGY AND FORMULATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/140073
Kind Code:
A1
Abstract:
Disclosed in the present invention are a cefathiamidine novel crystal compound and a crystallisation preparation method therefor, the cefathiamidine novel crystal compound being prepared using particle process crystal product molecular assembly and morphology optimisation technology. The present crystal compound has the characteristics of high purity, low impurity content, good fluidity, and good stability. Also disclosed in the present invention is a formulation prepared using said cefathiamidine: cefathiamidine for injection.

Inventors:
TAO LINGGANG (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
Application Number:
PCT/CN2016/085303
Publication Date:
August 24, 2017
Filing Date:
June 08, 2016
Export Citation:
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Assignee:
HAINAN LINGKANG PHARMACEUTICAL (CN)
UNIV TIANJIN (CN)
TAO LINGGANG (CN)
WANG JINGKANG (CN)
YIN QIUXIANG (CN)
HAO HONGXUN (CN)
International Classes:
C07D501/28; A61K31/545; A61P31/04; C07D501/04; C07D501/12
Foreign References:
CN105646534A2016-06-08
CN1385434A2002-12-18
CN102180890A2011-09-14
CN104530083A2015-04-22
CN104530082A2015-04-22
Other References:
LIU, XUEBIN ET AL.: "A New Purification Method of Crude Cefathiamidine", CHINESE JOURNAL OF ANTIBIOTICS, vol. 32, 31 October 2007 (2007-10-31), pages S1 - S2
Attorney, Agent or Firm:
BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
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